Skip to Main content Skip to Navigation
Journal articles

Human dental pulp stem cells: A sanctuary for relapsing Bartonella quintana

Abstract : Bartonella quintana is a facultative intracellular bacterium responsible for relapsing fever, an example of non-sterilizing immunity. The cellular sanctuary of B. quintana in-between febrile relapses remains unknown but repeated detection of B. quintana in dental pulp specimens suggested long-term half-life dental pulp stem cells (DPSCs) as candidates. As the capacity of DPSCs to internalize microscopic particles was unknown, we confirmed that DPSCs internalized B. quintana bacteria: Gimenez staining and fluorescence microscopy localized B. quintana bacteria inside DPSCs and this internalization did not affect the cellular multiplication of DPSCs during a one-month follow-up despite the increase in the bacterial load. B. quintana-infected DPSCs did not produce Tumor Necrosis Factor-α whereas an important production of Monocytes Chemoattractant Protein-1 was observed. These unprecedented observations suggest the possibility that DPSCs are shelters for the long-term persistence of B. quintana in the host, warranting further experimental and clinical investigations.
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03243147
Contributor : Isabelle Combe Connect in order to contact the contributor
Submitted on : Friday, June 4, 2021 - 3:13:34 PM
Last modification on : Tuesday, October 19, 2021 - 10:50:29 PM
Long-term archiving on: : Sunday, September 5, 2021 - 7:38:42 PM

File

1-s2.0-S0882401021000693-main....
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Collections

Citation

Hamadou Oumarou Hama, Attoumani Hamada, Gérard Aboudharam, Éric Ghigo, Michel Drancourt. Human dental pulp stem cells: A sanctuary for relapsing Bartonella quintana. Microbial Pathogenesis, Elsevier, 2021, 153, pp.104797. ⟨10.1016/j.micpath.2021.104797⟩. ⟨hal-03243147⟩

Share

Metrics

Record views

72

Files downloads

123