HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments

Abstract : Recent progress in reducing malaria cases and ensuing deaths is threatened by factors like mutations that induce resistance to artemisinin derivatives. Multiple drugs are currently in clinical trials for malaria treatment, including some with novel mechanisms of action. One of these, MMV390048, is a plasmodial kinase inhibitor. This review lists the recently developed molecules which target plasmodial kinases. A systematic review of the literature was performed using CAPLUS and MEDLINE databases from 2005 to 2020. It covers a total of 60 articles and describes about one hundred compounds targeting 22 plasmodial kinases. This work highlights the strong potential of compounds targeting plasmodial kinases for future drug therapies. However, the majority of the Plasmodium kinome remains to be explored.
Document type :
Journal articles
Complete list of metadata

Contributor : Nicolas Primas Connect in order to contact the contributor
Submitted on : Wednesday, June 2, 2021 - 1:30:45 PM
Last modification on : Tuesday, January 4, 2022 - 6:08:33 AM
Long-term archiving on: : Friday, September 3, 2021 - 7:14:17 PM


2020 Mustiere Molecules 25 594...
Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License



Romain Mustière, Patrice Vanelle, Nicolas Primas. Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments. Molecules, MDPI, 2020, 25, ⟨10.3390/molecules25245949⟩. ⟨hal-03246460⟩



Record views


Files downloads