2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one

Romain Mustière (1) , Patrice Vanelle (2) , Nicolas Primas (2)

1 LCC - Laboratoire de chimie de coordination
2 ICR - Institut de Chimie Radicalaire

As part of our ongoing scaffold hopping work on antimalarial 2-aminothieno[3,2-d]pyrimidin-4-one scaffold, we explored the dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one as a potential new antimalarial series. Using conditions found in the literature, we obtained 2-cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one with 93% yield through a simple treatment. It was then characterized by NMR (1H and 13C) and HRMS. Given the structure of this molecule, its aqueous stability was assessed to determine its suitability for biological tests. To our knowledge, this is the first dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one described

Keywords: boron; diazaborininone; thiophene; aqueous stability

Domains: Chemical Sciences

Romain Mustière, Patrice Vanelle, Nicolas Primas. 2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one. Molbank, 2021, 2021 (2), ⟨10.3390/m1221⟩. ⟨hal-03246463⟩