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Metal-Free Addition of Benzyl Halides to Aldehydes Using Super Electron Donors: Access to 3,4-Dihydroisocoumarins and 1,2-Diarylethanols

Abstract : We report here the intermolecular metal-free addition reaction of functionalized benzyl halides to aldehydes using a super electron donor (SED). The metal-free and mild conditions allowed the formation of 3,4-dihydroisocoumarins and 1,2diarylethanols with unprecedented functional group tolerance.
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https://hal-amu.archives-ouvertes.fr/hal-03254096
Contributor : Cédric Spitz <>
Submitted on : Tuesday, June 8, 2021 - 3:49:54 PM
Last modification on : Thursday, June 10, 2021 - 3:32:08 AM
Long-term archiving on: : Thursday, September 9, 2021 - 8:00:09 PM

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Cédric Spitz, Mélanie Matteudi, Guillaume Tintori, Julie Broggi, Thierry Terme, et al.. Metal-Free Addition of Benzyl Halides to Aldehydes Using Super Electron Donors: Access to 3,4-Dihydroisocoumarins and 1,2-Diarylethanols. Journal of Organic Chemistry, American Chemical Society, 2020, 85 (23), pp.15736-15742. ⟨10.1021/acs.joc.0c02374⟩. ⟨hal-03254096⟩

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