Localization of the toxic site of Naja mossambica cardiotoxins: small synthetic peptides express an in vivo lethality - Archive ouverte HAL Access content directly
Journal Articles Biochemical and Biophysical Research Communications Year : 1988

Localization of the toxic site of Naja mossambica cardiotoxins: small synthetic peptides express an in vivo lethality

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Abstract

Cardiotoxins are small basic proteins which cause heart failure when they are injected in vivo. In order to better understand their molecular mode of action, short peptides designed on the model of the first loop of the molecule of cardiotoxin IV from Naja mossambica mossambica venom have been synthetized by the solid-phase procedure of Merrifield. These peptides express lethality in mouse when they are injected intravenously. Taking into account the respective molecular weights, they are 3.5 to 5% as toxic as the cardiotoxin. Furthermore, the symptomatology they induce is undistinguishable from that induced by cardiotoxins. These results strongly support our previous hypothesis that the first loop of the molecule is the toxic site of cardiotoxins.

Dates and versions

hal-03261771 , version 1 (16-06-2021)

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Cite

P. Marchot, P.E. Bougis, B. Ceard, J. van Rietschoten, H. Rochat. Localization of the toxic site of Naja mossambica cardiotoxins: small synthetic peptides express an in vivo lethality. Biochemical and Biophysical Research Communications, 1988, 153 (2), pp.642-647. ⟨10.1016/s0006-291x(88)81143-4⟩. ⟨hal-03261771⟩
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