A. niger protein “EstA”, perhaps a new electrotactin, defines a new class of fungal esterases within the α/β hydrolase fold superfamily

Yves Bourne (1) , Alinda Hasper (2) , Henri Chahinian (3) , Ludovic Renault (4) , Marianick Juin (5) , Leo de Graaff (2) , Pascale Marchot (6)

1 AFMB - Architecture et fonction des Macromolécules Biologiques - UMR 6098
2 WUR - Wageningen University and Research [Wageningen]
3 CRN2M - Centre de recherche en neurobiologie - neurophysiologie de Marseille
4 CNRS - Centre National de la Recherche Scientifique
5 IMEP - Institut Méditerranéen d'Ecologie et de Paléoécologie
6 IP - Ingénierie des protéines

Protein EstA from Aspergillus niger was characterized through a multifaced approach involving molecular biology, bioinformatics, biophysical, biochemical and enzymatical analyses. EstA was identified as the lead member, within the superfamily of proteins with an alpha/beta-hydrolase fold, of a new class of fungal esterases that also contains predicted homologs from other fungus species of known broad host-range pathogenicity.

Mots clés: α/β-hydrolase; Chimera template; Electrotactin; Structural biology

Domaines: Sciences du Vivant [q-bio]

Yves Bourne, Alinda Hasper, Henri Chahinian, Ludovic Renault, Marianick Juin, et al.. A. niger protein “EstA”, perhaps a new electrotactin, defines a new class of fungal esterases within the α/β hydrolase fold superfamily. Chemico-Biological Interactions, 2005, 157-158, pp.395-396. ⟨10.1016/j.cbi.2005.10.072⟩. ⟨hal-03263187⟩