Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Structural insights into AChE inhibition by monoclonal antibodies

Abstract : The target sites of three inhibitory monoclonal antibodies, Elec403, 408 and 410, on eel AChE have been defined previously. Elec403 and 410 are directed toward distinct but overlapping epitopes at the enzyme peripheral site, while Elec408 binds to a distinct regulatory site on the enzyme surface, where the "back door" may be located. Elec410 also inhibits Bunganus fasciatus AChE. To investigate the molecular determinants for AChE inhibition by these antibodies, we have cloned and sequenced the IgGs, generated, purified, characterized the Fab molecules, and initiated crystallographic and theoretical modeling studies. Preliminary data are presented.
Document type :
Journal articles
Complete list of metadata
Contributor : Julien Caugant Connect in order to contact the contributor
Submitted on : Thursday, June 17, 2021 - 9:39:24 AM
Last modification on : Friday, January 21, 2022 - 12:26:01 PM

Links full text



Ludovic Renault, Sosthène Essono, Marianick Juin, Didier Boquet, Jacques Grassi, et al.. Structural insights into AChE inhibition by monoclonal antibodies. Chemico-Biological Interactions, Elsevier, 2005, 157-158, pp.397-400. ⟨10.1016/j.cbi.2005.10.073⟩. ⟨hal-03263196⟩



Record views