Journal articles
A bacterial pore-forming toxin forms aggregates in cells that resemble those associated with neurodegenerative diseases
Abstract : Listeria monocytogenes is a bacterial, facultative intracellular pathogen, which secretes a pore-forming toxin called listeriolysin O (LLO). LLO mediates the dissolution of the phagosomal membrane allowing L. monocytogenes to reach and grow in the host cytosolic compartment. In this study we report the localization of LLO secreted in infected cells. We described that LLO (i) forms small perinuclear aggregates, (ii) accumulates in large autophagosome-like structures and (iii) sequesters to large protein aggregates. The formation of protein aggregates required full LLO activity. Further characterization of protein aggregates indicated that they not only contained the active form of LLO but also polyubiquitinated proteins and p62, which are both common components of protein aggregates found in neurological diseases. Hence, a protein of bacterial origin could potentially follow the same fate as a toxic protein associated with neurodegenerative disease.
https://hal-amu.archives-ouvertes.fr/hal-03269633
Contributor : Julie Viala Connect in order to contact the contributor
Submitted on : Thursday, June 24, 2021 - 10:58:20 AM
Last modification on : Tuesday, October 19, 2021 - 10:58:57 PM
Long-term archiving on: : Saturday, September 25, 2021 - 6:17:52 PM
Contributor : Julie Viala Connect in order to contact the contributor
Submitted on : Thursday, June 24, 2021 - 10:58:20 AM
Last modification on : Tuesday, October 19, 2021 - 10:58:57 PM
Long-term archiving on: : Saturday, September 25, 2021 - 6:17:52 PM