Skip to Main content Skip to Navigation
Journal articles

Structural biology of type VI secretion systems

Abstract : Type VI secretion systems (T6SSs) are transenvelope complexes specialized in the transport of proteins or domains directly into target cells. These systems are versatile as they can target either eukaryotic host cells and therefore modulate the bacteria–host interaction and pathogenesis or bacterial cells and therefore facilitate access to a specific niche. These molecular machines comprise at least 13 proteins. Although recent years have witnessed advances in the role and function of these secretion systems, little is known about how these complexes assemble in the cell envelope. Interestingly, the current information converges to the idea that T6SSs are composed of two subassemblies, one resembling the contractile bacteriophage tail, whereas the other subunits are embedded in the inner and outer membranes and anchor the bacteriophage-like structure to the cell envelope. In this review, we summarize recent structural information on individual T6SS components emphasizing the fact that T6SSs are composite systems, adapting subunits from various origins.
Document type :
Journal articles
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03274797
Contributor : Eric Cascales <>
Submitted on : Wednesday, June 30, 2021 - 2:26:01 PM
Last modification on : Monday, July 12, 2021 - 9:39:13 AM

Links full text

Identifiers

Collections

Citation

E. Cascales, Christian Cambillau. Structural biology of type VI secretion systems. Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2012, 367 (1592), pp.1102-1111. ⟨10.1098/rstb.2011.0209⟩. ⟨hal-03274797⟩

Share

Metrics

Record views

18