Granulocyte Macrophage Colony-Stimulating Factor-Specific Autoantibodies and Cerebral Nocardia With Pulmonary Alveolar Proteinosis

Charlotte Berthoux (1) , Morgane Mailhe (1) , Frédéric Vély (2) , Clarisse Gauthier (3) , Jean-Louis Mège (1) , Jean-Christophe Lagier (1) , Cléa Melenotte (1)

1 MEPHI - Microbes évolution phylogénie et infections
2 CIML - Centre d'Immunologie de Marseille - Luminy
3 Hôpital Nord [CHU - APHM]

Abstract In this study, we report the history of a 40-year-old man with a primary cerebral abscess caused by Nocardia abscessus that led to the discovery of autoimmune pulmonary alveolar lipoproteinosis (anti-granulocyte-macrophage colony-stimulating factor [GM-CSF] autoantibodies). Anti-GM-CSF autoantibodies promote immunodeficiency and should be monitored to prevent opportunistic and disseminated infections and to diagnose asymptomatic pulmonary alveolar lipoproteinosis.

Keywords: Nocardia; Pulmonary alveolar proteinosis’ Anti-GM-CSF antibody

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Charlotte Berthoux, Morgane Mailhe, Frédéric Vély, Clarisse Gauthier, Jean-Louis Mège, et al.. Granulocyte Macrophage Colony-Stimulating Factor-Specific Autoantibodies and Cerebral Nocardia With Pulmonary Alveolar Proteinosis. Open Forum Infectious Diseases, 2021, 8 (2), ⟨10.1093/ofid/ofaa612⟩. ⟨hal-03279641⟩