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Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing

Madjid Morsli 1 Christine Zandotti 2 Aurelie Morand 3 Philippe Colson 4 Michel Drancourt 1
1 MEPHI - Microbes évolution phylogénie et infections
2 UVE - Unité des Virus Emergents
3 Service de pédiatrie spécialisée et médecine infantile (neurologie, pneumologie, maladies héréditaires du métabolisme) [Hôpital de la Timone - APHM]
4 VITROME - Vecteurs - Infections tropicales et méditerranéennes
Abstract : The current point-of-care diagnosis of enterovirus meningitis does not identify the viral genotype, which is prognostic. In this case report, more than 81% of an Echovirus 12 genome were detected and identified by metagenomic next-generation sequencing, directly from the cerebrospinal fluid collected in a 6-month-old child with meningeal syndrome and meningitis: introducing Echovirus 12 as an etiological agent of acute meningitis in the pediatric population.
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https://hal-amu.archives-ouvertes.fr/hal-03280504
Contributor : Isabelle Combe Connect in order to contact the contributor
Submitted on : Wednesday, July 7, 2021 - 1:39:35 PM
Last modification on : Friday, April 1, 2022 - 3:53:02 AM

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Madjid Morsli, Christine Zandotti, Aurelie Morand, Philippe Colson, Michel Drancourt. Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing. Pathogens, MDPI, 2021, 10 (5), pp.610. ⟨10.3390/pathogens10050610⟩. ⟨hal-03280504⟩

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