Challenges in exploring and manipulating the human skin microbiome

Manon Boxberger (1, 2) , Valérie Cenizo (3) , Nadim Cassir (1, 2) , Bernard La Scola (1, 2, 4)

1 MEPHI - Microbes évolution phylogénie et infections
2 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
3 Groupe L'Occitane R&D Department,
4 VITROME - Vecteurs - Infections tropicales et méditerranéennes

Abstract The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and extrinsic factors, with a focus on the pathobiological basis of skin aging. We also describe the most recent tools for investigating the skin microbiota composition and microbe-skin relationships and perspectives regarding the challenges of skin microbiome manipulation.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Manon Boxberger, Valérie Cenizo, Nadim Cassir, Bernard La Scola. Challenges in exploring and manipulating the human skin microbiome. Microbiome, 2021, 9 (1), ⟨10.1186/s40168-021-01062-5⟩. ⟨hal-03281725⟩