Skip to Main content Skip to Navigation
Journal articles

Expanding the occurrence of polysaccharides to the viral world: the case of Mimivirus

Abstract : The general perception of viruses is that they are small in terms of size and genome, and that they hijack the host machinery to glycosylate their capsid. Giant viruses subvert all these concepts: their particles are not small, and their genome is more complex than that of some bacteria. Regarding glycosylation, this concept has been already challenged by the finding that Chloroviruses have an autonomous glycosylation machinery, that produces oligosaccharides similar in size to those of small viruses (6-12 units), albeit different in structure compared to the viral counterparts. We report herein that Mimivirus possesses a glycocalyx made of two different polysaccharides, now challenging the concept that all viruses coat their capsids with oligosaccharides of discrete size. This discovery contradicts the paradigm that such macromolecules are absent in viruses, blurring the boundaries between giant viruses and the cellular world and opening new avenues in the field of viral glycobiology.
Document type :
Journal articles
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03294946
Contributor : Olivier Poirot <>
Submitted on : Wednesday, July 21, 2021 - 6:25:01 PM
Last modification on : Thursday, July 22, 2021 - 3:31:06 AM

Links full text

Identifiers

Collections

Citation

Anna Notaro, Yohann Couté, Lucid Belmudes, Maria Elena Laugieri, Annalisa Salis, et al.. Expanding the occurrence of polysaccharides to the viral world: the case of Mimivirus. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, ⟨10.1002/anie.202106671⟩. ⟨hal-03294946⟩

Share

Metrics

Record views

13