Efficient synthesis of N-substituted 1,3-thiazin-2-ones containing sulfonamide

Besma Bendif (1) , Nadjia Bensouilah (1) , Frédéric Dumur (2) , Malika Ibrahim-Ouali (3)

1 USTHB - Université des Sciences et de la Technologie Houari Boumediene = University of Sciences and Technology Houari Boumediene [Alger]
2 ICR - Institut de Chimie Radicalaire
3 ISM2 - Institut des Sciences Moléculaires de Marseille

Arkivoc 2019, part _, 0-0 Bendif. B et al.

Thiazinones containing sulfonamides are experiencing increased interest due to their importance in the design and development of new molecules of potential pharmaceutical interest. The synthesis of a series of new Nsubstituted 2H-1,3-thiazin-2-ones containing sulfonamide is described. The compounds were synthesized in good yields in a one-pot reaction starting from commercially available chlorosulfonyl isocyanate (CSI), 3chloro-1-propanethiol, and various primary and secondary aliphatic, aromatic or heteroaromatic amines. The structure of one of these compounds was established by X-ray crystallography. The compounds are being evaluated for their biological activity.

Mots clés: chlorosulfonyl isocyanate; sulfonamide; thiazin-2-one

Domaines: Matériaux

Besma Bendif, Nadjia Bensouilah, Frédéric Dumur, Malika Ibrahim-Ouali. Efficient synthesis of N-substituted 1,3-thiazin-2-ones containing sulfonamide. ARKIVOC - Online Journal of Organic Chemistry, 2021, 2021, pp.253 - 264. ⟨10.24820/ark.5550190.p011.528⟩. ⟨hal-03298821⟩