Skip to Main content Skip to Navigation
Journal articles

Sexual Dimorphism and Gender in Infectious Diseases

Abstract : Epidemiological studies and clinical observations show evidence of sexual dimorphism in infectious diseases. Women are at less risk than men when it comes to developing most infectious diseases. However, understanding these observations requires a gender approach that takes into account an analysis of both biological and social factors. The host’s response to infection differs in males and females because sex differences have an impact on hormonal and chromosomal control of immunity. Estradiol appears to confer protective immunity, while progesterone and testosterone suppress anti-infectious responses. In addition, genetic factors, including those associated with sex chromosomes, also affect susceptibility to infections. Finally, differences in occupational activities, lifestyle, and comorbidities play major roles in exposure to pathogens and management of diseases. Hence, considering sexual dimorphism as a critical variable for infectious diseases should be one of the steps taken toward developing personalized therapeutic approaches.
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03300038
Contributor : Isabelle Combe Connect in order to contact the contributor
Submitted on : Monday, September 6, 2021 - 4:44:06 PM
Last modification on : Tuesday, October 19, 2021 - 10:51:00 PM

File

fimmu-12-698121.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Laetitia Gay, Cléa Melenotte, Ines Lakbar, Soraya Mezouar, Christian Devaux, et al.. Sexual Dimorphism and Gender in Infectious Diseases. Frontiers in Immunology, Frontiers, 2021, 12, ⟨10.3389/fimmu.2021.698121⟩. ⟨hal-03300038⟩

Share

Metrics

Record views

69

Files downloads

16