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Unraveling the origin of SARS-CoV-2: is the model good?

Abstract : MacLean and colleagues recently published a very elegant analysis demonstrating that SARS-CoV-2 carries signs of positive selection and that it was already adapted to humans prior to the emergence of COVID-19. Using the Spillover theory as a reference model for zoonotic emergence, they conclude that SARS-CoV-2 must have acquired this human adaptation in bats. We reinterpreted the data from MacLean et al. using a different model of zoonotic emergence as reference, the Circulation model. The use of the Circulation model provides a more parsimonious interpretation showing that this adaptation to humans occurs in the human population after primo infection.
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Submitted on : Monday, September 6, 2021 - 4:29:37 PM
Last modification on : Friday, August 5, 2022 - 10:51:01 AM
Long-term archiving on: : Tuesday, December 7, 2021 - 7:11:29 PM


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Roger Frutos, Laurent Gavotte, Christian Devaux. Unraveling the origin of SARS-CoV-2: is the model good?. New Microbes and New Infections, 2021, pp.100918. ⟨10.1016/j.nmni.2021.100918⟩. ⟨hal-03300039⟩



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