Skip to Main content Skip to Navigation
Journal articles

SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence

Abstract : Background: We conducted this review to summarize the relation between viral mutation and infectivity of SARS-CoV-2 and also the severity of COVID-19 in vivo and in vitro. Method: Articles were identified through a literature search until 31 May 2021, in PubMed, Web of Science and Google Scholar. Results: Sixty-three studies were included. To date, most studies showed that the viral mutations, especially the D614G variant, correlate with a higher infectivity than the wild-type virus. However, the evidence of the association between viral mutation and severity of the disease is scant. A SARS-CoV-2 variant with a 382-nucleotide deletion was associated with less severe infection in patients. The 11,083G > U mutation was significantly associated with asymptomatic patients. By contrast, ORF1ab 4715L and S protein 614G variants were significantly more frequent in patients from countries where high fatality rates were also reported. The current evidence showed that variants of concern have led to increased infectivity and deteriorating epidemiological situations. However, the relation between this variant and severity of COVID-19 infection was contradictory. Conclusion: The COVID-19 pandemic continues to spread worldwide. It is necessary to anticipate large clinical cohorts to evaluate the virulence and transmissibility of SARS-CoV-2 mutants.
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03333825
Contributor : Isabelle Combe Connect in order to contact the contributor
Submitted on : Friday, September 10, 2021 - 1:53:48 PM
Last modification on : Saturday, September 11, 2021 - 3:36:50 AM

File

jcm-10-02635-v2.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Thi Loi Dao, van Thuan Hoang, Philippe Colson, Jean Christophe Lagier, Matthieu Million, et al.. SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence. Journal of Clinical Medicine, MDPI, 2021, 10 (12), pp.2635. ⟨10.3390/jcm10122635⟩. ⟨hal-03333825⟩

Share

Metrics

Record views

56

Files downloads

13