Role of glyphosate in the emergence of antimicrobial resistance in bacteria?

Didier Raoult (1) , Linda Hadjadj (1) , Sophie Alexandra Baron (1) , Jean-Marc Rolain (1)

1 MEPHI - Microbes évolution phylogénie et infections

There is a discrepancy between antibiotic use in medicine and agriculture in the intertropical zone and frequency of antibiotic resistance in clinical bacteria in these countries. We provide evidence that glyphosate (a herbicide but also an antibiotic drug) could be a possible driver of antibiotic resistance in countries where this herbicide is widely used because of modification of the microbial environment. Emergence of resistance in bacteria and fungi is correlated with glyphosate use in the world over the last 40 years.

Keywords: antibiotics antibiotic resistance; bacterial agriculture drug resistance; microbial herbicides bacteria fungus glyphosate multi-antibiotic resistance

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Didier Raoult, Linda Hadjadj, Sophie Alexandra Baron, Jean-Marc Rolain. Role of glyphosate in the emergence of antimicrobial resistance in bacteria?. Journal of Antimicrobial Chemotherapy, 2021, 76 (7), pp.1655-1657. ⟨10.1093/jac/dkab102⟩. ⟨hal-03334121⟩