Disseminated Cryptosporidium infection in an infant with CD40L deficiency

Fleur Dupuy (1) , Stéphane Valot (2) , Frédéric Dalle (3) , Arthur Sterin (4) , Coralie L’ollivier (5)

1 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
2 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
3 Laboratoire de parasitologie mycologie (CHU de Dijon)
4 TIMONE - Hôpital de la Timone [CHU - APHM]
5 VITROME - Vecteurs - Infections tropicales et méditerranéennes

The protozoan Cryptosporidium affects the digestive tract of humans and animals. Cryptosporidiosis leads to diarrhoea mimicking a cholera-like course with dehydration and may even result in death in immunodeficient patients, as patients with hyper-IgM syndrome. We describe a rare case of disseminated Cryptosporidium infection in a seven- year-old boy with CD40 L deficiency. During the pre-graft phase, the patient presented an intestinal cryptosporidiosis which became complicated few days later during the aplasia period with a cholangitis and pulmonary cryptosporidiosis. Cryptosporidium hominis was identified. After treatment with nitazoxanide and azithromycine the patient was doing well.

Keywords: Cryptosporidium; Disseminated; CD40L deficiency

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Fleur Dupuy, Stéphane Valot, Frédéric Dalle, Arthur Sterin, Coralie L’ollivier. Disseminated Cryptosporidium infection in an infant with CD40L deficiency. IDCases, 2021, 24, pp.e01115. ⟨10.1016/j.idcr.2021.e01115⟩. ⟨hal-03334255⟩