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Disseminated Cryptosporidium infection in an infant with CD40L deficiency

Abstract : The protozoan Cryptosporidium affects the digestive tract of humans and animals. Cryptosporidiosis leads to diarrhoea mimicking a cholera-like course with dehydration and may even result in death in immunodeficient patients, as patients with hyper-IgM syndrome. We describe a rare case of disseminated Cryptosporidium infection in a seven- year-old boy with CD40 L deficiency. During the pre-graft phase, the patient presented an intestinal cryptosporidiosis which became complicated few days later during the aplasia period with a cholangitis and pulmonary cryptosporidiosis. Cryptosporidium hominis was identified. After treatment with nitazoxanide and azithromycine the patient was doing well.
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Submitted on : Monday, September 6, 2021 - 9:53:54 AM
Last modification on : Sunday, June 26, 2022 - 10:26:53 AM
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Fleur Dupuy, Stéphane Valot, Frédéric Dalle, Arthur Sterin, Coralie L’ollivier. Disseminated Cryptosporidium infection in an infant with CD40L deficiency. IDCases, Elsevier, 2021, 24, pp.e01115. ⟨10.1016/j.idcr.2021.e01115⟩. ⟨hal-03334255⟩



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