Skip to Main content Skip to Navigation
Conference papers

BODY-ON-A-CHIP: ON-CHIP HEART RECEIVING METABOLITES FROM ON-CHIP LIVER

Abstract : We report on the development of an integrated microfluidic and multi-electrode array (MEA) system housed in a microbioreactor for Body-on-a-Chip applications. On a single chip, we successfully demonstrate the use of this system by connecting an on-Chip Liver and an on-Chip Heart. We demonstrate that acylated dihydropyrimidinone (DHPM), when added to the on-Chip Liver, is deacylated and results in DHPM, a well-known calcium channel blocker, delivered to the on-Chip Heart by on-Chip organ-to-organ interconnectivity. Deacylated DHPM delivery to the cardiomyocytes is verified by MEA measurements of cardiomyocyte electroactivity and Liquid chromatography-mass spectrometry (LCMS) of the cardiomyocyte medium.
Document type :
Conference papers
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03349096
Contributor : Adam Williamson Connect in order to contact the contributor
Submitted on : Monday, September 20, 2021 - 11:38:40 AM
Last modification on : Tuesday, September 21, 2021 - 7:20:40 AM

File

149_0581.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : hal-03349096, version 1

Collections

Citation

Adam Williamson, Uta Fernekorn, Sukhdeep Singh, Andreas Schober. BODY-ON-A-CHIP: ON-CHIP HEART RECEIVING METABOLITES FROM ON-CHIP LIVER. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Oct 2013, Freiburg, Germany. ⟨hal-03349096⟩

Share

Metrics

Record views

18

Files downloads

4