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Communication Dans Un Congrès Année : 2013

BODY-ON-A-CHIP: ON-CHIP HEART RECEIVING METABOLITES FROM ON-CHIP LIVER

Résumé

We report on the development of an integrated microfluidic and multi-electrode array (MEA) system housed in a microbioreactor for Body-on-a-Chip applications. On a single chip, we successfully demonstrate the use of this system by connecting an on-Chip Liver and an on-Chip Heart. We demonstrate that acylated dihydropyrimidinone (DHPM), when added to the on-Chip Liver, is deacylated and results in DHPM, a well-known calcium channel blocker, delivered to the on-Chip Heart by on-Chip organ-to-organ interconnectivity. Deacylated DHPM delivery to the cardiomyocytes is verified by MEA measurements of cardiomyocyte electroactivity and Liquid chromatography-mass spectrometry (LCMS) of the cardiomyocyte medium.
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Dates et versions

hal-03349096 , version 1 (20-09-2021)

Identifiants

  • HAL Id : hal-03349096 , version 1

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Adam Williamson, Uta Fernekorn, Sukhdeep Singh, Andreas Schober. BODY-ON-A-CHIP: ON-CHIP HEART RECEIVING METABOLITES FROM ON-CHIP LIVER. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Oct 2013, Freiburg, Germany. ⟨hal-03349096⟩

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