Sibling status, home birth, tattoos and stitches are risk factors for chronic hepatitis B virus infection in Senegalese children: A cross‐sectional survey - Archive ouverte HAL Access content directly
Journal Articles Journal of Viral Hepatitis Year : 2021

Sibling status, home birth, tattoos and stitches are risk factors for chronic hepatitis B virus infection in Senegalese children: A cross‐sectional survey

Cyril Bérenger
  • Function : Author
Marwân-Al-Qays Bousmah
Patrizia M. Carrieri
Maëlle de Sèze
  • Function : Author
Tchadine Djaogol
Gwenaëlle Maradan
  • Function : Author
Carole Treibich
El Hadji Ba Ba
  • Function : Author
Fambaye Dièye
  • Function : Author
Assane Diouf
  • Function : Author
Elhadji Bilal Faye
  • Function : Author
Assane Ndiaye
  • Function : Author
Mouhamadou Baba Sow
  • Function : Author
Anna Julienne Selbé Ndiaye
  • Function : Author
Samba Ndiour
  • Function : Author
Philippe Halfon
  • Function : Author
  • PersonId : 900177
Sofiane Mohamed
  • Function : Author
Nicolas Rouveau
  • Function : Author
  • PersonId : 1089635
Maria‐camila Calvo Cortès
  • Function : Author
Gabrièle Laborde‐balen
  • Function : Author
Martine Audibert
Fatou Fall
  • Function : Author
Ibrahima Gueye
  • Function : Author
Karine Lacombe
  • Function : Author
  • PersonId : 854081
Moussa Seydi
  • Function : Author
  • PersonId : 1089634
Yusuke Shimakawa
Muriel Vray
  • Function : Author
  • PersonId : 943083

Abstract

Sub-Saharan Africa's hepatitis B virus (HBV) burden is primarily due to infection in infancy. However, data on chronic HBV infection prevalence and associated risk factors in children born post-HBV vaccination introduction are scarce. We estimated hepatitis B surface antigen (HBsAg) prevalence and risk factors in Senegalese children born during the HBV vaccination era. In 2018-2019, a community-based cross-sectional survey was conducted in Senegal among children born between 2004 and 2015 (ie after the three-dose HBV vaccine series was introduced (2004) but before the birth dose's introduction (2016)). HBsAg-positive children were identified using dried blood spots. A standardized questionnaire collected socioeconomic information. Data were age-sex weighted and calibrated to be representative of children living in the study area. Risk factors associated with HBsAg positivity were identified using negative binomial regression. Among 1,327 children, 17 were HBsAg-positive (prevalence = 1.23% (95% confidence interval [CI] 0.61-1.85)). Older age (adjusted incidence-rate ratio [aIRR] 1.31 per one-year increase, 95% CI 1.10-1.57), home vs healthcare facility delivery (aIRR 3.55, 95% CI 1.39-9.02), stitches (lifetime) (aIRR 4.79; 95% CI 1.84-12.39), tattoos (aIRR 8.97, 95% CI 1.01-79.11) and having an HBsAg-positive sibling with the same mother (aIRR 3.05, 95% CI 1.09-8.57) were all independently associated with HBsAg positivity. The low HBsAg prevalence highlights the success of the Senegalese HBV vaccination program. To further reduce HBV acquisition in children, high-risk groups, including pregnant women and siblings of HBsAg-positive individuals, must be screened. Vital HBV infection prevention measures include promoting delivery in healthcare facilities, and increasing awareness of prevention and control procedures.
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Dates and versions

hal-03355358 , version 1 (28-01-2022)

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Lauren Périères, Camelia Protopopescu, Gora Lo, Fabienne Marcellin, El Hadji Ba, et al.. Sibling status, home birth, tattoos and stitches are risk factors for chronic hepatitis B virus infection in Senegalese children: A cross‐sectional survey. Journal of Viral Hepatitis, 2021, 28 (11), pp.1515-1525. ⟨10.1111/jvh.13589⟩. ⟨hal-03355358⟩
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