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Journal Articles Infectious Disorders - Drug Targets Year : 2021

Vaccines for COVID-19: A Review of Feasibility and Effectiveness

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Esmaeil Mehraeen
Omid Dadras
  • Function : Author
Amir Masoud Afsahi
  • Function : Author
Amirali Karimi
  • Function : Author
Mehrzad Mohssenipour
  • Function : Author
Pegah Mirzapour
  • Function : Author
Alireza Barzegary
  • Function : Author
Farzane Behnezhad
  • Function : Author
Pedram Habibi
  • Function : Author
Mohammad Amin Salehi
  • Function : Author
Farzin Vahedi
  • Function : Author
Mohammad Heydari
  • Function : Author
Shaghayegh Kianzad
  • Function : Author
Banafsheh Moradmand-Badie
  • Function : Author
Mohammad Javaherian
  • Function : Author
Seyedahmad Seyedalinaghi
  • Function : Author
Jean-Marc Sabatier


Introduction: Many potential vaccines for COVID-19 are being studied, and several studies have reported the results of these vaccines. We aimed to review the current evidence of the feasibility and effectiveness of Vaccines for COVID-19. Methods: A search was carried out utilizing the keywords in the online databases, including Scopus,Web of Science, PubMed, Embase, and Cochrane. We included both human and non-human studies because of the vaccine novelty, which could limit our ability to include sufficient human studies. Results: The review of studies showed that several SARS-CoV-2 vaccines are under development; different platforms are being used, including eight vaccines are adenovirus-based vectors, six vaccines are RNA-based formulations, one vaccine is DNA-based formulations, and other vaccines are using other platforms, including lipid nano particles. Conclusion: It is crucial to gather as much clinically relevant evidence as possible regarding the immunogenicity, efficacy, and safety profiles of these vaccines and adhere wisely to CDC protocols and guidelines of vaccine production.
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Dates and versions

hal-03357919 , version 1 (29-09-2021)



Esmaeil Mehraeen, Omid Dadras, Amir Masoud Afsahi, Amirali Karimi, Mehrzad Mohssenipour, et al.. Vaccines for COVID-19: A Review of Feasibility and Effectiveness. Infectious Disorders - Drug Targets, 2021, 21, ⟨10.2174/1871526521666210923144837⟩. ⟨hal-03357919⟩
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