Antimicrobial Peptides: A Potent Alternative to Antibiotics

Mariam Rima (1) , Mohamad Rima (2) , Ziad Fajloun (2) , Jean-Marc Sabatier (3) , Burkhard Bechinger (4) , Thierry Naas (1)

1 Université Paris-Saclay
2 DEPT. OF COMPUT. & COMMUN. - Lebanese Univ., Tripoli, Lebanon
3 INP - Institut de neurophysiopathologie
4 Institut de Chimie de Strasbourg

Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future.

Mots clés: ESKAPE; antibiotic resistance; antimicrobial peptides; multidrug resistance

Domaines: Autre; Biochimie, Biologie Moléculaire

Mariam Rima, Mohamad Rima, Ziad Fajloun, Jean-Marc Sabatier, Burkhard Bechinger, et al.. Antimicrobial Peptides: A Potent Alternative to Antibiotics. 2021, 10 (9), pp.1095. ⟨10.3390/antibiotics10091095⟩. ⟨hal-03357922⟩