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Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression

Abstract : Innate lymphoid cells (ILCs) are tissue-resident lymphocytes differing from conventional T lymphocytes in having no antigen-specific receptors. ILCs include natural killer (NK) cells, helper-like ILC1s, ILC2s, and ILC3s, and lymphoid tissue-inducer (LTi) cells. Tumor ILCs are frequently found in various cancers, but their roles in cancer immunity and immunotherapy remain largely unclear. We report here the single-cell characterization of blood and gut helper-like ILC subsets in healthy conditions and in colorectal cancer (CRC). The healthy gut contains ILC1s, ILC3s, and ILC3/NKs, but no ILC2s. Additional tumor-specific ILC1-like and ILC2 subsets were identified in CRC patients. Signaling lymphocytic activation molecule family member 1 (SLAMF1) was found to be selectively expressed on tumor-specific ILCs, and higher levels of SLAMF1+ ILCs were observed in the blood of CRC patients. The SLAMF1-high group of CRC patients had a significantly higher survival rate than the SLAMF1-low group, suggesting that SLAMF1 is an anti-tumor biomarker in CRC.
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https://hal-amu.archives-ouvertes.fr/hal-03374574
Contributor : Anita DUMENIL Connect in order to contact the contributor
Submitted on : Tuesday, October 12, 2021 - 11:07:03 AM
Last modification on : Friday, April 1, 2022 - 3:45:21 AM

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Jingjing Qi, Adeline Crinier, Bertrand Escalière, Youqiong Ye, Zhengting Wang, et al.. Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression. Cell Reports Medicine, 2021, 2 (8), pp.100353. ⟨10.1016/j.xcrm.2021.100353⟩. ⟨hal-03374574⟩

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