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Journal articles

Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop

Lu Bai 1 Margaux Vienne 2 Ling Tang 1 Yann Kerdiles 2 Marion Etiennot 2 Bertrand Escalière 2 Justine Galluso 2 Haiming Wei 1 Rui Sun 1, 3 Eric Vivier 2, 4, 5 Hui Peng 1 Zhigang Tian 1
1 USTC - University of Science and Technology of China [Hefei]
2 CIML - Centre d'Immunologie de Marseille - Luminy
3 UCAS - University of Chinese Academy of Sciences [Beijing]
4 Innate Pharma
5 TIMONE - Hôpital de la Timone [CHU - APHM]
Abstract : The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains Lin − Sca-1 + Mac-1 + hematopoietic stem cells derived from the fetal liver. This population includes Lin − CD122 + CD49a + progenitors that can generate liver ILC1s but not conventional natural killer cells. Interferon-γ (IFN-γ) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-γR + liver progenitors. Thus, an IFN-γ–dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver.
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https://hal-amu.archives-ouvertes.fr/hal-03375153
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Submitted on : Tuesday, October 12, 2021 - 3:32:31 PM
Last modification on : Tuesday, May 10, 2022 - 3:23:06 AM

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CNRS | UNIV-AMU

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Lu Bai, Margaux Vienne, Ling Tang, Yann Kerdiles, Marion Etiennot, et al.. Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop. Science, American Association for the Advancement of Science (AAAS), 2021, 371 (6536), pp.eaba4177. ⟨10.1126/science.aba4177⟩. ⟨hal-03375153⟩

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