TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current

Sungjae Yoo (1) , Catarina Santos (1) , Ana Reynders (1) , Irène Marics (1) , Pascale Malapert (1) , Stéphane Gaillard (2) , Aude Charron (1) , Sophie Ugolini (3) , Rafaëlle Rossignol (3) , Abderazzak El Khallouqi (4) , Jean-Yves Springael (5) , Marc Parmentier (6) , Andrew J Saurin (1) , Jean-Marc Goaillard (7) , Francis Castets (1) , Nadine Clerc (1) , Aziz Moqrich (1)

1 IBDM - Institut de Biologie du Développement de Marseille
2 Phenotype-expertise
3 CIML - Centre d'Immunologie de Marseille - Luminy
4 JGU - Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University
5 ULB - Université libre de Bruxelles
6 ULB - Département d'Informatique [Bruxelles]
7 UNIS - Inserm U1072 - Unité de Neurobiologie des canaux Ioniques et de la Synapse

Highlights d TAFA4 reverses inflammatory, postoperative, and nerve injury-induced mechanical pain d TAFA4-mediated antihypersensitive effect requires functional LDL receptor family members d SNI alters spinal I A in opposite direction in excitatory and inhibitory interneurons d TAFA4 reverses SNI-induced alteration of I A in both interneuron subtypes

Keywords: TAFA4; injury-induced mechanical pain; IA and Ih; gating neurons; LDL-receptors; RAP

Domains: Life Sciences [q-bio]

Sungjae Yoo, Catarina Santos, Ana Reynders, Irène Marics, Pascale Malapert, et al.. TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current. Cell Reports, 2021, 37 (4), pp.109884. ⟨10.1016/j.celrep.2021.109884⟩. ⟨hal-03406182⟩