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TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current

Sungjae Yoo 1 Catarina Santos 1 Ana Reynders 1 Irène Marics 1 Pascale Malapert 1 Stéphane Gaillard 2 Aude Charron 1 Sophie Ugolini 3 Rafaëlle Rossignol 3 Abderazzak El Khallouqi 4 Jean-Yves Springael 5 Marc Parmentier 6 Andrew Saurin 1 Jean-Marc Goaillard 7 Francis Castets 1 Nadine Clerc 1 Aziz Moqrich 1
1 IBDM - Institut de Biologie du Développement de Marseille
2 Phenotype-expertise
3 CIML - Centre d'Immunologie de Marseille - Luminy
4 JGU - Johannes Gutenberg - Universität Mainz
5 ULB - Université libre de Bruxelles
6 ULB - Département d'Informatique [Bruxelles]
7 UMR_S 1072
Abstract : Highlights d TAFA4 reverses inflammatory, postoperative, and nerve injury-induced mechanical pain d TAFA4-mediated antihypersensitive effect requires functional LDL receptor family members d SNI alters spinal I A in opposite direction in excitatory and inhibitory interneurons d TAFA4 reverses SNI-induced alteration of I A in both interneuron subtypes
Keywords : TAFA4 injury-induced mechanical pain IA and Ih gating neurons LDL-receptors RAP
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Journal articles
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https://hal-amu.archives-ouvertes.fr/hal-03406182
Contributor : Sébastien Poulain Connect in order to contact the contributor
Submitted on : Wednesday, October 27, 2021 - 5:01:50 PM
Last modification on : Tuesday, January 4, 2022 - 6:48:54 AM

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Sungjae Yoo, Catarina Santos, Ana Reynders, Irène Marics, Pascale Malapert, et al.. TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current. Cell Reports, Elsevier Inc, 2021, 37 (4), pp.109884. ⟨10.1016/j.celrep.2021.109884⟩. ⟨hal-03406182⟩

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