TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current
Abstract
Highlights d TAFA4 reverses inflammatory, postoperative, and nerve injury-induced mechanical pain d TAFA4-mediated antihypersensitive effect requires functional LDL receptor family members d SNI alters spinal I A in opposite direction in excitatory and inhibitory interneurons d TAFA4 reverses SNI-induced alteration of I A in both interneuron subtypes
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