Helical Bisphosphinites in Asymmetric Tsuji‐Trost Allylation: a Remarkable P:Pd Ratio Effect
Résumé
This article discloses a study on a chiral bis-phosphorylated-helical ligand in the palladium-catalyzed Tsuji-Trost allylation. The use of 2,15-bisphosphinite[6]helicenes allowed to evidence a remarkable ligand effect, in which the (R) and (S) isomeric products can be selectively formed as a direct function of the amount of ligand introduced. Study of the organometallic species involved through 31P NMR analysis of a model complex and X-Ray diffraction analysis together with DFT calculations shed light on this
phenomenon.
Domaines
Catalyse
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