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Outcomes of Patients With Advanced NSCLC From the Intergroupe Francophone de Cancérologie Thoracique Biomarkers France Study by KRAS Mutation Subtypes

Anne-Marie Ruppert 1, 2 Michèle Beau-Faller 3, 4 Didier Debieuvre 5 L'Houcine Ouafik 6, 7 Virginie Westeel 8, 9 Isabelle Rouquette 10 Julien Mazières 11 Pierre-Paul Bringuier 12 Isabelle Monnet 13 Fabienne Escande 14 Charles Ricordel 15, 16 Jean-Philippe Merlio 17 Henri Janicot 18 Antoinette Lemoine 19 Pascal Foucher 20 Michel Poudenx 21 Franck Morin 22 Alexandra Langlais 22 Pierre-Jean Souquet 23 Fabrice Barlesi 24 Marie Wislez 25, 26 
1 GRC 4 - Theranoscan [CHU Tenon]
CHU Tenon [AP-HP] : GRC 4, SU - Sorbonne Université : GRC 4
Abstract : Introduction: KRAS mutations are detected in 20% to 30% of NSCLC. However, KRAS mutation subtypes may differently influence the outcome of patients with advanced NSCLC. Conclusions: KRAS mutation subtypes influenced neither treatment responses nor outcomes. The KRAS G12C mutation was detected in 41.5% of patients, who are now eligible for potent and specific G12C inhibitors.
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https://hal-amu.archives-ouvertes.fr/hal-03430888
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Submitted on : Tuesday, November 16, 2021 - 2:17:33 PM
Last modification on : Friday, October 28, 2022 - 3:17:54 AM
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Anne-Marie Ruppert, Michèle Beau-Faller, Didier Debieuvre, L'Houcine Ouafik, Virginie Westeel, et al.. Outcomes of Patients With Advanced NSCLC From the Intergroupe Francophone de Cancérologie Thoracique Biomarkers France Study by KRAS Mutation Subtypes. Jto Clinical and Research Reports, 2020, 1 (3), pp.100052. ⟨10.1016/j.jtocrr.2020.100052⟩. ⟨hal-03430888⟩

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