Journal articles

Management of anaphylaxis due to COVID‐19 vaccines in the elderly

Jean Bousquet ^{1, 2, 3} Ioana Agache ⁴ Hubert Blain ² Marek Jutel ⁵ Maria Teresa Ventura ⁶ Margitta Worm ⁷ Stefano del Giacco ⁸ Athanasios Benetos ⁹ Beatrice Maria Bilo ¹⁰ Wienczyslawa Czarlewski ¹¹ Amir Hamzah Abdul Latiff ¹² Mona Al‐ahmad Elizabeth Angier ¹³ Isabella Annesi‐maesano ¹⁴ Marina Atanaskovic‐markovic ¹⁵ Claus Bachert ¹⁶ Annick Barbaud ^{17, 18} Anna Bedbrook ¹² Kazi Bennoor ¹⁹ Elena Camelia Berghea ²⁰ Carsten Bindslev‐jensen ²¹ Sergio Bonini ²² Sinthia Bosnic‐anticevich ²³ Knut Brockow ²⁴ Luisa Brussino ²⁵ Paulo Camargos ²⁶ G. Walter Canonica ²⁷ Victoria Cardona ²⁸ Pedro Carreiro‐martins ²⁹ Ana Carriazo Thomas Casale ³⁰ Jean‐christoph Caubet ³¹ Lorenzo Cecchi ³² Antonio Cherubini George Christoff ³³ Derek Chu ³⁴ Alvaro Cruz ³⁵ Dejan Dokic ³⁶ yehia El‐gamal† ³⁷ Motohiro Ebisawa ³⁸ Bernadette Eberlein ²⁴ John Farrell Montserrat Fernandez‐rivas ³⁹ Wytske Fokkens ⁴⁰ Joao Fonseca ⁴¹ yadong Gao ⁴² Gaëtan Gavazzi ⁴³ Radoslaw Gawlik ⁴⁴ Asli Gelincik ⁴⁵ Bilun Gemicioğlu ⁴⁶ Maia Gotua Olivier Guérin ⁴⁷ Tari Haahtela ⁴⁸ Karin Hoffmann‐sommergruber Hans Jürgen Hoffmann Maja Hofmann Martin Hrubisko Maddalena Illario Carla Irani Zhanat Ispayeva Juan Carlos Ivancevich Kaja Julge Igor Kaidashev Musa Khaitov Edward Knol Helga Kraxner Piotr Kuna Violeta Kvedariene Antti Lauerma Lan Le Vincent Le Moing ^{49, 50} Michael Levin Renaud Louis Olga Lourenco Vera Mahler Finbarr Martin Andrea Matucci Branislava Milenkovic Stéphanie Miot ² Emma Montella Mario Morais‐almeida Charlotte Mortz Joaquim Mullol Leyla Namazova‐baranova Hugo Neffen Kristof Nekam Marek Niedoszytko Mikaëla Odemyr Robyn O’hehir yoshitaka Okamoto Markus Ollert Oscar Palomares Nikolaos Papadopoulos Petr Panzner Giovanni Passalacqua Vincenzo Patella Mirko Petrovic Oliver Pfaar Nhân Pham‐thi Davor Plavec Todor Popov Marysia Recto Frederico Regateiro Jacques Reynes Regina Roller‐winsberger yves Rolland ⁵¹ Antonino Romano Carmen Rondon Menachem Rottem Philip Rouadi Nathalie Salles Boleslaw Samolinski Alexandra Santos Faradiba Sarquis Joaquin Sastre Jos M. G. A. Schols Nicola Scichilone Anna Sediva Mohamed Shamji Aziz Sheikh Isabel Skypala Sylwia Smolinska Milena Sokolowska Bernardo Sousa‐pinto Milan Sova Rafael Stelmach Gunter Sturm Charlotte Suppli Ulrik Ana Maria Todo‐bom Sanna Toppila‐salmi Ioanna Tsiligianni Maria Torres Eva Untersmayr Marilyn Urrutia Pereira Arunas Valiulis Joana Vitte ^{52, 53, 14} Alessandra Vultaggio Dana Wallace Jolanta Walusiak‐skorupa De‐yun Wang Susan Waserman Arzu yorgancioglu Osman yusuf Mario Zernotti Mihaela Zidarn Tomas Chivato Cezmi Akdis Torsten Zuberbier Ludger Klimek

1 Humboldt-Universität zu Berlin

2 CHU Montpellier

3 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon

4 Transylvania University

5 Wroclaw Medical University [Wrocław, Pologne]

6 UNIBA - University of Bari Aldo Moro

7 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]

8 University of Cagliari

9 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy

10 UNIVPM - Università Politecnica delle Marche [Ancona]

11 Medical Consulting Czarlewski

12 Universiti Putra Malaysia

13 University of Southampton

14 IDESP - Institut Desbrest de santé publique

15 University of Belgrade [Belgrade]

16 Ghent University Hospital

17 Service de Médecine Interne = Hôpital de jour de médecine [CHU Tenon]

18 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique

19 Dhaka Shishu Hospital [Bangladesh]

20 UMPCD - University of Medicine and Pharmacy “Carol Davila” Bucharest

21 OUH - Odense University Hospital

22 Italian National Research Council

23 The University of Sydney

24 TUM - Technische Universität München = Technical University of Munich

25 UNITO - Università degli studi di Torino = University of Turin

26 UFMG - Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil]

27 IRCCS Research Hospital, Milan

28 Vall d'Hebron University Hospital [Barcelona]

29 Centro Hospitalar de Lisboa Central E.P.E

30 USF - University of South Florida [Tampa]

31 HUG - Geneva University Hospital

32 Azienda Usl Toscana centro [Firenze]

33 Софийски университет = Sofia University

34 McMaster University [Hamilton, Ontario]

35 State University of Bahia

36 Institute of Public Health of Republic of North Macedonia [Skopje]

37 ASU - Ain Shams University

38 Sagamihara National Hospital

39 IdISSC - Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain]

40 Amsterdam UMC - Amsterdam University Medical Center

41 Universidade do Porto = University of Porto

42 Wuhan University [China]

43 CHU Grenoble

44 Silesian University of Medicine

45 Istanbul Faculty of Medicine

46 Cerrahpasa Faculty of Medicine

47 CHU Nice - Centre Hospitalier Universitaire de Nice

48 Helsinki University Hospital [Helsinki, Finlande]

49 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

50 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes

51 CHU Toulouse [Toulouse]

52 MEPHI - Microbes évolution phylogénie et infections

53 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection

Abstract : Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.

Keywords : COVID -19 vaccines Adrenaline Anaphylaxis Older

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology / Bacteriology

Life Sciences [q-bio] / Microbiology and Parasitology / Virology

Life Sciences [q-bio] / Microbiology and Parasitology / Parasitology

Life Sciences [q-bio] / Human health and pathology / Cardiology and cardiovascular system

Life Sciences [q-bio] / Human health and pathology / Emerging diseases

Life Sciences [q-bio] / Human health and pathology / Infectious diseases

Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03437014
Contributor : Isabelle COMBE Connect in order to contact the contributor
Submitted on : Friday, November 19, 2021 - 4:09:55 PM
Last modification on : Saturday, June 25, 2022 - 3:34:53 AM