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Management of anaphylaxis due to COVID‐19 vaccines in the elderly

Jean Bousquet 1, 2, 3 Ioana Agache 4 Hubert Blain 2 Marek Jutel 5 Maria Teresa Ventura 6 Margitta Worm 7 Stefano del Giacco 8 Athanasios Benetos 9 Beatrice Maria Bilo 10 Wienczyslawa Czarlewski 11 Amir Hamzah Abdul Latiff 12 Mona Al‐ahmad Elizabeth Angier 13 Isabella Annesi‐maesano 14 Marina Atanaskovic‐markovic 15 Claus Bachert 16 Annick Barbaud 17, 18 Anna Bedbrook 12 Kazi Bennoor 19 Elena Camelia Berghea 20 Carsten Bindslev‐jensen 21 Sergio Bonini 22 Sinthia Bosnic‐anticevich 23 Knut Brockow 24 Luisa Brussino 25 Paulo Camargos 26 G. Walter Canonica 27 Victoria Cardona 28 Pedro Carreiro‐martins 29 Ana Carriazo Thomas Casale 30 Jean‐christoph Caubet 31 Lorenzo Cecchi 32 Antonio Cherubini George Christoff 33 Derek Chu 34 Alvaro Cruz 35 Dejan Dokic 36 yehia El‐gamal† 37 Motohiro Ebisawa 38 Bernadette Eberlein 24 John Farrell Montserrat Fernandez‐rivas 39 Wytske Fokkens 40 Joao Fonseca 41 yadong Gao 42 Gaëtan Gavazzi 43 Radoslaw Gawlik 44 Asli Gelincik 45 Bilun Gemicioğlu 46 Maia Gotua Olivier Guérin 47 Tari Haahtela 48 Karin Hoffmann‐sommergruber Hans Jürgen Hoffmann Maja Hofmann Martin Hrubisko Maddalena Illario Carla Irani Zhanat Ispayeva Juan Carlos Ivancevich Kaja Julge Igor Kaidashev Musa Khaitov Edward Knol Helga Kraxner Piotr Kuna Violeta Kvedariene Antti Lauerma Lan Le Vincent Le Moing 49, 50 Michael Levin Renaud Louis Olga Lourenco Vera Mahler Finbarr Martin Andrea Matucci Branislava Milenkovic Stéphanie Miot 2 Emma Montella Mario Morais‐almeida Charlotte Mortz Joaquim Mullol Leyla Namazova‐baranova Hugo Neffen Kristof Nekam Marek Niedoszytko Mikaëla Odemyr Robyn O’hehir yoshitaka Okamoto Markus Ollert Oscar Palomares Nikolaos Papadopoulos Petr Panzner Giovanni Passalacqua Vincenzo Patella Mirko Petrovic Oliver Pfaar Nhân Pham‐thi Davor Plavec Todor Popov Marysia Recto Frederico Regateiro Jacques Reynes Regina Roller‐winsberger yves Rolland 51 Antonino Romano Carmen Rondon Menachem Rottem Philip Rouadi Nathalie Salles Boleslaw Samolinski Alexandra Santos Faradiba Sarquis Joaquin Sastre Jos M. G. A. Schols Nicola Scichilone Anna Sediva Mohamed Shamji Aziz Sheikh Isabel Skypala Sylwia Smolinska Milena Sokolowska Bernardo Sousa‐pinto Milan Sova Rafael Stelmach Gunter Sturm Charlotte Suppli Ulrik Ana Maria Todo‐bom Sanna Toppila‐salmi Ioanna Tsiligianni Maria Torres Eva Untersmayr Marilyn Urrutia Pereira Arunas Valiulis Joana Vitte 52, 53, 14 Alessandra Vultaggio Dana Wallace Jolanta Walusiak‐skorupa De‐yun Wang Susan Waserman Arzu yorgancioglu Osman yusuf Mario Zernotti Mihaela Zidarn Tomas Chivato Cezmi Akdis Torsten Zuberbier Ludger Klimek 
Abstract : Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.
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https://hal-amu.archives-ouvertes.fr/hal-03437014
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Submitted on : Friday, November 19, 2021 - 4:09:55 PM
Last modification on : Saturday, June 25, 2022 - 3:34:53 AM

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Jean Bousquet, Ioana Agache, Hubert Blain, Marek Jutel, Maria Teresa Ventura, et al.. Management of anaphylaxis due to COVID‐19 vaccines in the elderly. Allergy, Wiley, 2021, 76 (10), pp.2952-2964. ⟨10.1111/all.14838⟩. ⟨hal-03437014⟩

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