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Book Sections Year : 2020

A Practical Guide to Orthology Resources


Many resources exist which collect information on orthologous genes and provide this information to the research community. However, the algorithms used to collect orthologs, the type of data available for analysis or download, the range of organisms included, as well as the user-friendliness vary greatly between different orthology databases. In this review, we present a practical guide to the best-known orthology resources: we here briefly discuss their algorithmic details, review their taxonomic coverage and illustrate their user-friendliness. Moreover, we evaluate their capability to detect remotely conserved orthologs and to resolve inparalog relationships in gene families. Finally, we assess the availability and ease of usage of orthology search engines offered by orthology database providers for local usage.

Dates and versions

hal-03451246 , version 1 (26-11-2021)



Paul de Boissier, Bianca H Habermann. A Practical Guide to Orthology Resources. Evolutionary Biology—A Transdisciplinary Approach, Springer International Publishing, pp.41-77, 2020, ⟨10.1007/978-3-030-57246-4_3⟩. ⟨hal-03451246⟩
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