Mechanobiological model to study the influence of screw design and surface treatment on osseointegration

Nicolas Rousseau (1, 2) , Patrick Chabrand (2) , Arnaud Destainville (3) , Olivier Richart (1) , Jean-Louis Milan (4, 2, 2)

1 Selenium Medical, 9049 rue de Québec, CS80875, 17043 La Rochelle, France
2 ISM - Institut des Sciences du Mouvement Etienne Jules Marey
3 Abys Medical, 40 rue Chef de Baie, 17000 La Rochelle, France
4 IML - Institut du Mouvement et de l’appareil Locomoteur [Hôpital Sainte-Marguerite - APHM]

This study aims at suggesting a new approach to peri-implant healing models, providing a set of taxis-diffusion-reaction equations under the combined influence of mechanical and biochemical factors. Early events of osseointegration were simulated for titanium screw implants inserted into a pre-drilled trabecular bone environment, up to twelve weeks of peri-implant bone healing. Simulations showed the ability of the model to reproduce biological events occurring at the implant interface through osteogenesis. Implants with shallow healing chamber showed higher proportions of lamellar bone, enhanced by the increase of mechanical stimulation. Osteoconduction was observed through the surface treatment model and similar bone healing patterns compared to in vivo studies.

Mots clés: Osseointegration; Mechanobiological model; Implant design; Surface treatment; Finite element simulation

Domaines: Biomécanique [physics.med-ph]; Modélisation et simulation

Nicolas Rousseau, Patrick Chabrand, Arnaud Destainville, Olivier Richart, Jean-Louis Milan. Mechanobiological model to study the influence of screw design and surface treatment on osseointegration. Computer Methods in Biomechanics and Biomedical Engineering, 2021, pp.1-17. ⟨10.1080/10255842.2021.1950144⟩. ⟨hal-03467261⟩