Role of CD146 (MCAM) in Physiological and Pathological Angiogenesis—Contribution of New Antibodies for Therapy - Archive ouverte HAL Access content directly
Journal Articles Biomedicines Year : 2020

Role of CD146 (MCAM) in Physiological and Pathological Angiogenesis—Contribution of New Antibodies for Therapy

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Hussein Fayyad-Kazan

Abstract

The fundamental role of cell adhesion molecules in mediating various biological processes as angiogenesis has been well-documented. CD146, an adhesion molecule of the immunoglobulin superfamily, and its soluble form, constitute major players in both physiological and pathological angiogenesis. A growing body of evidence shows soluble CD146 to be significantly elevated in the serum or interstitial fluid of patients with pathologies related to deregulated angiogenesis, as autoimmune diseases, obstetric and ocular pathologies, and cancers. To block the undesirable effects of this molecule, therapeutic antibodies have been developed. Herein, we review the multifaceted functions of CD146 in physiological and pathological angiogenesis and summarize the interest of using monoclonal antibodies for therapeutic purposes.

Dates and versions

hal-03504350 , version 1 (29-12-2021)

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Ahmad Joshkon, Xavier Heim, Cléa Dubrou, Richard Bachelier, Wael Traboulsi, et al.. Role of CD146 (MCAM) in Physiological and Pathological Angiogenesis—Contribution of New Antibodies for Therapy. Biomedicines, 2020, 8 (12), pp.633. ⟨10.3390/biomedicines8120633⟩. ⟨hal-03504350⟩
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