CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases

Xavier Heim (1, 2, 3) , Ahmad Joshkon (1, 2) , Julien Bermudez (1, 2, 4) , Richard Bachelier (1, 2) , Cléa Dubrou (1, 2) , José Boucraut (3, 5) , Alexandrine Foucault-Bertaud (1, 2) , Aurelie Leroyer (1, 2) , Francoise Dignat-George (1, 2, 3) , Marcel Blot-Chabaud (1, 2) , Nathalie Bardin (1, 2, 3)

1 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
2 TIMONE - Hôpital de la Timone [CHU - APHM]
3 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
4 Hôpital Nord [CHU - APHM]
5 INT - Institut de Neurosciences de la Timone

CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis. In this review, we will focus on how CD146 and sCD146 contribute to the pathogenesis of the aforementioned autoimmune diseases and discuss the relevance of considering it as a biomarker in these pathologies.

Mots clés: CD146; autoimmunity; inflammation angiogenesis; soluble CD146

Domaines: Sciences du Vivant [q-bio]

Xavier Heim, Ahmad Joshkon, Julien Bermudez, Richard Bachelier, Cléa Dubrou, et al.. CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases. Biomedicines, 2020, 8 (12), pp.592. ⟨10.3390/biomedicines8120592⟩. ⟨hal-03504352⟩