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CD146 (Cluster of Differentiation 146)

Abstract : CD146 (cluster of differentiation 146) is an adhesion molecule that is expressed by different cells constituting vessels, particularly endothelial cells. The last 30 years of research in this field have shown that CD146 plays a key role in the control of several vessel functions. Three forms of CD146 have been described, including 2 transmembrane isoforms and a soluble protein that is detectable in the plasma. These CD146 forms mediate pleiotropic functions through homophilic and heterophilic interactions with proteins present on surrounding partners. Several studies used neutralizing antibodies, siRNA, or genetically modified mice to demonstrate the involvement of CD146 in the regulation of angiogenesis, vascular permeability, and leukocyte transmigration. In this review, we will focus on the current knowledge of the roles of CD146 in vascular homeostasis and diseases associated with endothelial dysfunction.
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Contributor : Aurelie Leroyer Connect in order to contact the contributor
Submitted on : Wednesday, December 29, 2021 - 9:57:40 AM
Last modification on : Thursday, July 14, 2022 - 4:13:47 AM

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Aurelie Leroyer, Muriel Blin, Richard Bachelier, Nathalie Bardin, Marcel Blot-Chabaud, et al.. CD146 (Cluster of Differentiation 146). Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39 (6), pp.1026-1033. ⟨10.1161/ATVBAHA.119.312653⟩. ⟨hal-03504363⟩



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