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Post-vaccine COVID-19 in patients with multiple sclerosis or neuromyelitis optica

Abstract : Introduction: Recent studies suggested that anti-CD20 and fingolimod may be associated with lower anti-spike protein-based immunoglobulin-G response following COVID-19 vaccination. We evaluated if COVID-19 occurred despite vaccination among patients with multiple sclerosis (MS) and neuromyelitis optica (NMO), using the COVISEP registry. Case series: We report 18 cases of COVID-19 after two doses of BNT162b2-vaccination, 13 of which treated with anti-CD20 and four with fingolimod. COVID-19 severity was mild. Discussion: These results reinforce the recommendation for a third COVID-19 vaccine dose among anti-CD20 treated patients, and stress the need for a prospective clinical and biological study on COVID-19 vaccine efficacy among MS and NMO patients.
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Submitted on : Friday, January 14, 2022 - 11:53:55 AM
Last modification on : Sunday, May 1, 2022 - 3:17:46 AM
Long-term archiving on: : Friday, April 15, 2022 - 6:39:11 PM

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Edouard Januel, Jérôme de Seze, Patrick Vermersch, Elisabeth Maillart, Bertrand Bourre, et al.. Post-vaccine COVID-19 in patients with multiple sclerosis or neuromyelitis optica. Multiple Sclerosis Journal, SAGE Publications, 2021, pp.135245852110497. ⟨10.1177/13524585211049737⟩. ⟨hal-03526127⟩

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