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Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Ludwig Kappos 1 Amit Bar-Or 2, 3 Bruce Cree 4 Robert Fox 5 Gavin Giovannoni 6 Ralf Gold 7 Patrick Vermersch 8 Douglas Arnold 9 Sophie Arnould 10 Tatiana Scherz 10 Christian Wolf 11 Erik Wallström 10 Frank Dahlke 10 Anat Achiron Lutz Achtnichts Kadriye Agan Gulsen Akman-Demir Alison Allen Jack Antel Alfredo Rodriguez Antiguedad Michelle Apperson Angela Applebee Guillermo Izquierdo Ayuso Masayuki Baba Ovidiu Bajenaru Rodica Balasa Belgin Petek Balci Michael Barnett Ann Bass Veit Becker Mihaela Bejinariu Florian Then Bergh Arnfin Bergmann Evanthia Bernitsas Achim Berthele Virender Bhan Felix Bischof Randall John Bjork Gregg Blevins Matthias Boehringer Thomas Boerner Robert Bonek James Bowen Allen Bowling Alexey Boyko Cavit Boz Vera Bracknies Stefan Braune Vincenzo Brescia Morra Bruno Brochet Waldemar Brola Paul Kenneth Brownstone Miroslav Brozman Donald Brunet Ioan Buraga Margaret Burnett Mathias Buttmann Helmut Butzkueven Jonathan Cahill Jonathan Calkwood William Camu Mark Cascione Giovani Castelnovo Diego Centonze Joao Cerqueira Andrew Chan Andrea Cimprichova Stanley Cohan Giancarlo Comi Jill Conway Joanna Cooper John Corboy Jorge Correale Brian Costell David Cottrell Patricia Coyle Matthew Craner Liying Cui Luis Cunha Anna Czlonkowska Ana Martins da Silva Joao de Sa Jérôme de Seze Marc Debouverie Jan Debruyne Danny Decoo Gilles Defer Tobias Derfuss Norma Deri Bhupesh Dihenia Peter Dioszeghy Vladimir Donath Benedicte Dubois Martin Duddy Pierre Duquette Gilles Edan Husnu Efendi Stanton Elias Peter Emrich Bonaventura Casanova Estruch Evgeniy Evdoshenko Juergen Faiss Alexander Fedyanin Wolfgang Feneberg Jiske Fermont Oscar Fernandez Fernandez Francisco Coret Ferrer Katharina Fink Helen Ford Corey Ford Ada Francia Mark Freedman Benjamin Frishberg Simonetta Galgani George Garmany Klaus Gehring Jeffrey Gitt Claudio Gobbi Lawrence Goldstick Rafael Arroyo Gonzalez Francois Grandmaison Nikolaos Grigoriadis Olga Grigorova Luigi Maria Edoardo Grimaldi Jeffrey Gross Katrin Gross-Paju Mark Gudesblatt Daniel Guillaume Judith Haas Viera Hancinova Anca Hancu Orla Hardiman Arndt Harmjanz Fedor Heidenreich G Hengstman Joseph Herbert Mark Herring Suzanne Hodgkinson Olaf Hoffmann Werner Hofmann William Honeycutt Le Hanh Hua Dehui Huang Yining Huang Deren Huang Raymond Hupperts Piroska Imre Alan Keith Jacobs Gabor Jakab Elzbieta Jasinska Kenichi Kaida Jolanta Kalnina Ara Kaprelyan Guntis Karelis Dimitrios Karussis Amos Katz Farit Khabirov Bhupendra Khatri Takashi Kimura Ilya Kister Rasa Kizlaitiene Eleonora Klimova Juergen Koehler Aparna Komatineni Anselm Kornhuber Krisztina Kovacs Agnes Koves Wojciech Kozubski Georgi Krastev Lauren Krupp Egon Kurca Christoph Lassek Guy Laureys Liesly Lee Eckart Lensch Fritz Leutmezer Hongzeng Li Ralf Linker Michael Linnebank Petra Liskova Cristina Llanera Jiahong Lu Andreas Lutterotti Jan Lycke Richard Macdonell Maciej Maciejowski Mathias Maeurer Rim Magzhanov Eva-Maria Maida Lina Malciene Yang Mao-Draayer Girolama Alessandra Marfia Clyde Markowitz Vasileios Mastorodimos Klotild Matyas Jose Meca-Lallana Juan Antonio Garcia Merino Ioan Gheorghe Mihetiu Ivan Milanov Aaron Miller Andrejs Millers Massimiliano Mirabella Masanori Mizuno Xavier Montalban Lilina Montoya Masahiro Mori Stefanie Mueller Jin Nakahara Yuji Nakatsuji Scott Newsome Richard Nicholas a Scott Nielsen Esmaeil Nikfekr Ugo Nocentini Chiyoko Nohara Kyoichi Nomura Miroslav Odinak Tomas Olsson B van Oosten Celia Oreja-Guevara Patrick Oschmann James Overell Andrew Pachner Gyula Panczel Massimo Pandolfo Caroline Papeix Liliana Patrucco Jean Pelletier 12, 13, 14 Raul Piedrabuena Misha Pless Udo Polzer Krisztian Pozsegovits Daiva Rastenyte Sebastian Rauer Gerd Reifschneider Roberto Rey Syed Rizvi Derrick Robertson Jose Martinez Rodriguez David Rog Homayoun Roshanisefat Vernon Rowe Csilla Rozsa Susan Rubin Stanislaw Rusek Francesco Saccà Takahiko Saida Antonio Vasco Salgado Victoria Eugenia Fernandez Sanchez Kalina Sanders Maria Satori Denis Sazonov Elio Angelo Scarpini Eugen Schlegel Myriam Schluep Stephan Schmidt Erich Scholz H Schrijver Matthias Schwab Raymond Schwartz James Scott Krzysztof Selmaj Stuart Shafer Basil Sharrack Ivan Shchukin Yuko Shimizu Penko Shotekov Arno Siever Karl-Otto Sigel Scott Silliman Magdolna Simo Mihaela Simu Vladimiro Sinay Antonio Escartin Siquier Aksel Siva Ondrej Skoda Andrew Solomon Martin Stangel Dusan Stefoski Brian Steingo Igor Stolyarov Pavel Stourac Katrin Strassburger-Krogias Erik Strauss Olaf Stuve Ivaylo Tarnev Antonios Tavernarakis Cristina Ramo Tello Murat Terzi Veronika Ticha Marina Ticmeanu Klaus Tiel-Wilck Toomas Toomsoo Niall Tubridy Mark Tullman Hayrettin Tumani Peter Turcani Ben Turner Antonio Uccelli Francisco Javier Olascoaga Urtaza Marta Vachova Attila Valikovics Silke Walter Bart van Wijmeersch Ludo Vanopdenbosch Joerg Weber Sara Weiss Robert Weissert Timothy West Heinz Wiendl Sandrine Wiertlewski Brigitte Wildemann Barbara Willekens L Visser Galina Vorobeychik Xianhao Xu Takashi Yamamura Yi Yang Sergio Martinez Yelamos Michael Yeung Alan Zacharias Marvin Zelkowitz Uwe Zettl Meini Zhang Hongyu Zhou Ulf Zieman Tjalf Ziemssen
1 Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital, University of Basel, Basel
2 Center for Neuroinflammation and Neurotherapeutics, and Multiple Sclerosis Division, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
3 Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC
4 UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA
5 Mellen Centre for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH
6 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London
7 Department of Neurology St. Josef-Hospital, Ruhr University Bochum, Germany
8 INFINITE (Ex-Liric) - Institute for Translational Research in Inflammation - U 1286
9 Montreal Neurological Institute, McGill University, Montreal, QC, Canada; NeuroRx Research, Montreal, QC
10 Novartis Pharma AG
11 Lycalis, Brussels
12 AP-HM, CHU Timone, Pole de Neurosciences Cliniques, Department of Neurology, Marseille, France.
13 CRMBM - Centre de résonance magnétique biologique et médicale
14 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]
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https://hal-amu.archives-ouvertes.fr/hal-03541636
Contributor : Jean-Philippe Ranjeva Connect in order to contact the contributor
Submitted on : Monday, January 24, 2022 - 6:01:15 PM
Last modification on : Wednesday, March 23, 2022 - 3:51:30 PM

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UNIV-AMU | CRMBM | CNRS | UNIV-LILLE

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Ludwig Kappos, Amit Bar-Or, Bruce Cree, Robert Fox, Gavin Giovannoni, et al.. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. The Lancet, Elsevier, 2018, 391 (10127), pp.1263-1273. ⟨10.1016/S0140-6736(18)30475-6⟩. ⟨hal-03541636⟩

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