Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Ludwig Kappos (1) , Amit Bar-Or (2, 3) , Bruce Cree (4) , Robert Fox (5) , Gavin Giovannoni (6) , Ralf Gold (7) , Patrick Vermersch (8) , Douglas Arnold (9) , Sophie Arnould (10) , Tatiana Scherz (10) , Christian Wolf (11) , Erik Wallström (10) , Frank Dahlke (10) , Anat Achiron , Lutz Achtnichts , Kadriye Agan , Gulsen Akman-Demir , Alison Allen , Jack Antel , Alfredo Rodriguez Antiguedad , Michelle Apperson , Angela Applebee , Guillermo Izquierdo Ayuso , Masayuki Baba , Ovidiu Bajenaru , Rodica Balasa , Belgin Petek Balci , Michael Barnett , Ann Bass , Veit Becker , Mihaela Bejinariu , Florian Then Bergh , Arnfin Bergmann , Evanthia Bernitsas , Achim Berthele , Virender Bhan , Felix Bischof , Randall John Bjork , Gregg Blevins , Matthias Boehringer , Thomas Boerner , Robert Bonek , James Bowen , Allen Bowling , Alexey Boyko , Cavit Boz , Vera Bracknies , Stefan Braune , Vincenzo Brescia Morra , Bruno Brochet , Waldemar Brola , Paul Kenneth Brownstone , Miroslav Brozman , Donald Brunet , Ioan Buraga , Margaret Burnett , Mathias Buttmann , Helmut Butzkueven , Jonathan Cahill , Jonathan Calkwood , William Camu , Mark Cascione , Giovani Castelnovo , Diego Centonze , Joao Cerqueira , Andrew Chan , Andrea Cimprichova , Stanley Cohan , Giancarlo Comi , Jill Conway , Joanna Cooper , John Corboy , Jorge Correale , Brian Costell , David Cottrell , Patricia Coyle , Matthew Craner , Liying Cui , Luis Cunha , Anna Czlonkowska , Ana Martins da Silva , Joao de Sa , Jérôme de Seze , Marc Debouverie , Jan Debruyne , Danny Decoo , Gilles Defer , Tobias Derfuss , Norma Deri , Bhupesh Dihenia , Peter Dioszeghy , Vladimir Donath , Benedicte Dubois , Martin Duddy , Pierre Duquette , Gilles Edan , Husnu Efendi , Stanton Elias , Peter Emrich , Bonaventura Casanova Estruch , Evgeniy Evdoshenko , Juergen Faiss , Alexander Fedyanin , Wolfgang Feneberg , Jiske Fermont , Oscar Fernandez Fernandez , Francisco Coret Ferrer , Katharina Fink , Helen Ford , Corey Ford , Ada Francia , Mark Freedman , Benjamin Frishberg , Simonetta Galgani , George Garmany , Klaus Gehring , Jeffrey Gitt , Claudio Gobbi , Lawrence Goldstick , Rafael Arroyo Gonzalez , Francois Grandmaison , Nikolaos Grigoriadis , Olga Grigorova , Luigi Maria Edoardo Grimaldi , Jeffrey Gross , Katrin Gross-Paju , Mark Gudesblatt , Daniel Guillaume , Judith Haas , Viera Hancinova , Anca Hancu , Orla Hardiman , Arndt Harmjanz , Fedor Heidenreich , G Hengstman , Joseph Herbert , Mark Herring , Suzanne Hodgkinson , Olaf Hoffmann , Werner Hofmann , William Honeycutt , Le Hanh Hua , Dehui Huang , Yining Huang , Deren Huang , Raymond Hupperts , Piroska Imre , Alan Keith Jacobs , Gabor Jakab , Elzbieta Jasinska , Kenichi Kaida , Jolanta Kalnina , Ara Kaprelyan , Guntis Karelis , Dimitrios Karussis , Amos Katz , Farit Khabirov , Bhupendra Khatri , Takashi Kimura , Ilya Kister , Rasa Kizlaitiene , Eleonora Klimova , Juergen Koehler , Aparna Komatineni , Anselm Kornhuber , Krisztina Kovacs , Agnes Koves , Wojciech Kozubski , Georgi Krastev , Lauren Krupp , Egon Kurca , Christoph Lassek , Guy Laureys , Liesly Lee , Eckart Lensch , Fritz Leutmezer , Hongzeng Li , Ralf Linker , Michael Linnebank , Petra Liskova , Cristina Llanera , Jiahong Lu , Andreas Lutterotti , Jan Lycke , Richard Macdonell , Maciej Maciejowski , Mathias Maeurer , Rim Magzhanov , Eva-Maria Maida , Lina Malciene , Yang Mao-Draayer , Girolama Alessandra Marfia , Clyde Markowitz , Vasileios Mastorodimos , Klotild Matyas , Jose Meca-Lallana , Juan Antonio Garcia Merino , Ioan Gheorghe Mihetiu , Ivan Milanov , Aaron Miller , Andrejs Millers , Massimiliano Mirabella , Masanori Mizuno , Xavier Montalban , Lilina Montoya , Masahiro Mori , Stefanie Mueller , Jin Nakahara , Yuji Nakatsuji , Scott Newsome , Richard Nicholas , a Scott Nielsen , Esmaeil Nikfekr , Ugo Nocentini , Chiyoko Nohara , Kyoichi Nomura , Miroslav Odinak , Tomas Olsson , B van Oosten , Celia Oreja-Guevara , Patrick Oschmann , James Overell , Andrew Pachner , Gyula Panczel , Massimo Pandolfo , Caroline Papeix , Liliana Patrucco , Jean Pelletier (12, 13, 14) , Raul Piedrabuena , Misha Pless , Udo Polzer , Krisztian Pozsegovits , Daiva Rastenyte , Sebastian Rauer , Gerd Reifschneider , Roberto Rey , Syed Rizvi , Derrick Robertson , Jose Martinez Rodriguez , David Rog , Homayoun Roshanisefat , Vernon Rowe , Csilla Rozsa , Susan Rubin , Stanislaw Rusek , Francesco Saccà , Takahiko Saida , Antonio Vasco Salgado , Victoria Eugenia Fernandez Sanchez , Kalina Sanders , Maria Satori , Denis Sazonov , Elio Angelo Scarpini , Eugen Schlegel , Myriam Schluep , Stephan Schmidt , Erich Scholz , H Schrijver , Matthias Schwab , Raymond Schwartz , James Scott , Krzysztof Selmaj , Stuart Shafer , Basil Sharrack , Ivan Shchukin , Yuko Shimizu , Penko Shotekov , Arno Siever , Karl-Otto Sigel , Scott Silliman , Magdolna Simo , Mihaela Simu , Vladimiro Sinay , Antonio Escartin Siquier , Aksel Siva , Ondrej Skoda , Andrew Solomon , Martin Stangel , Dusan Stefoski , Brian Steingo , Igor Stolyarov , Pavel Stourac , Katrin Strassburger-Krogias , Erik Strauss , Olaf Stuve , Ivaylo Tarnev , Antonios Tavernarakis , Cristina Ramo Tello , Murat Terzi , Veronika Ticha , Marina Ticmeanu , Klaus Tiel-Wilck , Toomas Toomsoo , Niall Tubridy , Mark Tullman , Hayrettin Tumani , Peter Turcani , Ben Turner , Antonio Uccelli , Francisco Javier Olascoaga Urtaza , Marta Vachova , Attila Valikovics , Silke Walter , Bart van Wijmeersch , Ludo Vanopdenbosch , Joerg Weber , Sara Weiss , Robert Weissert , Timothy West , Heinz Wiendl , Sandrine Wiertlewski , Brigitte Wildemann , Barbara Willekens , L Visser , Galina Vorobeychik , Xianhao Xu , Takashi Yamamura , Yi Yang , Sergio Martinez Yelamos , Michael Yeung , Alan Zacharias , Marvin Zelkowitz , Uwe Zettl , Meini Zhang , Hongyu Zhou , Ulf Zieman , Tjalf Ziemssen

1 Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital, University of Basel, Basel
2 Center for Neuroinflammation and Neurotherapeutics, and Multiple Sclerosis Division, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
3 Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC
4 UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA
5 Mellen Centre for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH
6 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London
7 Department of Neurology St. Josef-Hospital, Ruhr University Bochum, Germany
8 INFINITE (Ex-Liric) - Institute for Translational Research in Inflammation - U 1286
9 Montreal Neurological Institute, McGill University, Montreal, QC, Canada; NeuroRx Research, Montreal, QC
10 Novartis Pharma AG
11 Lycalis, Brussels
12 AP-HM, CHU Timone, Pole de Neurosciences Cliniques, Department of Neurology, Marseille, France.
13 CRMBM - Centre de résonance magnétique biologique et médicale
14 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]

Domains: Life Sciences [q-bio]; Human health and pathology

Ludwig Kappos, Amit Bar-Or, Bruce Cree, Robert Fox, Gavin Giovannoni, et al.. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. The Lancet, 2018, 391 (10127), pp.1263-1273. ⟨10.1016/S0140-6736(18)30475-6⟩. ⟨hal-03541636⟩