Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia

Claudie Bosc (1, 2) , Estelle Saland (1, 3) , Aurélie Bousard (4) , Noémie Gadaud (1, 3, 5, 6) , Marie Sabatier (1, 3) , Guillaume Cognet (1, 3) , Thomas Farge (1, 3) , Emeline Boet (1, 3) , Mathilde Gotanègre (7, 3) , Nesrine Aroua (1, 3) , Pierre-Luc Mouchel (1, 3, 5, 6) , Nathaniel Polley (1, 3) , Clément Larrue (1, 3) , Eléonore Kaphan (1, 3) , Muriel Picard (8) , Ambrine Sahal (1, 3) , Latifa Jarrou (1, 3) , Marie Tosolini (1) , Florian Rambow (4) , Florence Cabon (1, 3) , Nathalie Nicot (9) , Laura Poillet-Perez (1, 3) , Yujue Wang (10) , Xiaoyang Su (10) , Quentin Fovez (11) , Jérôme Kluza (11) , Rafael José Argüello (12) , Céline Mazzotti (1, 13) , Hervé Avet-Loiseau (1, 13) , François Vergez (1, 3, 5, 6) , Jérôme Tamburini (14) , Jean-Jacques Fournié (1, 3) , Ing Tiong (15) , Andrew Wei (15) , Tony Kaoma (9) , Jean-Christophe Marine (4) , Christian Récher (1, 3, 5, 6) , Lucille Stuani (1) , Carine Joffre (1, 3) , Jean-Emmanuel Sarry (1, 3)

1 CRCT - Centre de Recherches en Cancérologie de Toulouse
2 LabEx Toucan
3 LabEx Toucan - Toulouse
4 VIB-KU-CCB - Leuven Center for Cancer Biology
5 UTPS - Université Toulouse III Paul Sabatier - Faculté de médecine Purpan
6 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
7 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]
8 Pôle Anesthésie Réanimation [CHU de Toulouse]
9 LIH - Luxembourg Institute of Health
10 Rutgers cancer institute of New Jersey [Newark, NJ]
11 CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277
12 CIML - Centre d'Immunologie de Marseille - Luminy
13 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
14 UNIGE - Université de Genève = University of Geneva
15 The Alfred Hospital and Monash University - Department of Clinical Haematology - Melbourne

Domains: Life Sciences [q-bio]

Claudie Bosc, Estelle Saland, Aurélie Bousard, Noémie Gadaud, Marie Sabatier, et al.. Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia. Nature Cancer, 2021, 2 (11), pp.1204-1223. ⟨10.1038/s43018-021-00264-y⟩. ⟨hal-03565962⟩