Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia

Claudie Bosc; Estelle Saland; Aurélie Bousard; Noémie Gadaud; Marie Sabatier; Guillaume Cognet; Thomas Farge; Emeline Boet; Mathilde Gotanègre; Nesrine Aroua; Pierre-Luc Mouchel; Nathaniel Polley; Clément Larrue; Eléonore Kaphan; Muriel Picard; Ambrine Sahal; Latifa Jarrou; Marie Tosolini; Florian Rambow; Florence Cabon; Nathalie Nicot; Laura Poillet-Perez; yujue Wang; Xiaoyang Su; Quentin Fovez; Jérôme Kluza; Rafael José Argüello; Céline Mazzotti; Hervé Avet-Loiseau; François Vergez; Jérôme Tamburini; Jean-Jacques Fournié; Ing Tiong; Andrew Wei; Tony Kaoma; Jean-Christophe Marine; Christian Récher; Lucille Stuani; Carine Joffre; Jean-Emmanuel Sarry

doi:10.1038/s43018-021-00264-y

Journal articles

Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia

Claudie Bosc ^{1, 2} Estelle Saland ^{1, 3} Aurélie Bousard ⁴ Noémie Gadaud ^{1, 3, 5, 6} Marie Sabatier ^{1, 3} Guillaume Cognet ^{1, 3} Thomas Farge ^{1, 3} Emeline Boet ^{1, 3} Mathilde Gotanègre ^{7, 3} Nesrine Aroua ^{1, 3} Pierre-Luc Mouchel ^{1, 3, 5, 6} Nathaniel Polley ^{1, 3} Clément Larrue ^{1, 3} Eléonore Kaphan ^{1, 3} Muriel Picard ⁸ Ambrine Sahal ^{1, 3} Latifa Jarrou ^{1, 3} Marie Tosolini ¹ Florian Rambow ⁴ Florence Cabon ^{1, 3} Nathalie Nicot ⁹ Laura Poillet-Perez ^{1, 3} yujue Wang ¹⁰ Xiaoyang Su ¹⁰ Quentin Fovez ¹¹ Jérôme Kluza ¹¹ Rafael José Argüello ¹² Céline Mazzotti ^{1, 13} Hervé Avet-Loiseau ^{1, 13} François Vergez ^{1, 3, 5, 6} Jérôme Tamburini ¹⁴ Jean-Jacques Fournié ^{1, 3} Ing Tiong ¹⁵ Andrew Wei ¹⁵ Tony Kaoma ⁹ Jean-Christophe Marine ⁴ Christian Récher ^{1, 3, 5, 6} Lucille Stuani ¹ Carine Joffre ^{1, 3} Jean-Emmanuel Sarry ^{1, 3}

1 CRCT - Centre de Recherches en Cancérologie de Toulouse

2 LabEx Toucan

3 LabEx Toucan - Toulouse

4 VIB-KU-CCB - Leuven Center for Cancer Biology

5 UT3 UTPS - Université Toulouse III Paul Sabatier - Faculté de médecine Purpan

6 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole

7 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]

8 CHU de Toulouse, Pole d'anesthésie Réanimation, Hôpital Paule de Viguier, Toulouse F-31059, France

9 LIH - Luxembourg Institute of Health

10 Rutgers cancer institute of New Jersey [Newark, NJ]

11 CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277

12 CIML - Centre d'Immunologie de Marseille - Luminy

13 CHU Toulouse [Toulouse]

14 University of Geneva [Switzerland]

15 The Alfred Hospital and Monash University - Department of Clinical Haematology - Melbourne

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Journal articles

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Life Sciences [q-bio]

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Submitted on : Friday, February 11, 2022 - 12:04:28 PM
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Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia

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Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia

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