Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins? - Archive ouverte HAL Access content directly
Journal Articles Cancers Year : 2020

Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?

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Abstract

Cancer treatments are constantly evolving with new approaches to improve patient outcomes. Despite progresses, too many patients remain refractory to treatment due to either the development of resistance to therapeutic drugs and/or metastasis occurrence. Growing evidence suggests that these two barriers are due to transient survival mechanisms that are similar to those observed during stress response. We review the literature and current available open databases to study the potential role of stress response and, most particularly, the involvement of Stress Granules (proteins) in cancer. We propose that Stress Granule proteins may have prognostic value for patients.

Dates and versions

hal-03606494 , version 1 (11-03-2022)

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Anaïs Aulas, Pascal Finetti, Shawn Lyons, François Bertucci, Daniel Birnbaum, et al.. Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?. Cancers, 2020, 12 (9), pp.2470. ⟨10.3390/cancers12092470⟩. ⟨hal-03606494⟩
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