Scientific summary from the Morgan Welch MD Anderson Cancer Center Inflammatory Breast Cancer (IBC) program 10th Anniversary Conference

Wendy Woodward (1) , Massimo Cristofanilli (2) , Sofia Merajver (3, 4) , Steven van Laere (5) , Lajos Pusztai (6) , François Bertucci (7) , Fedor Berditchevski (8) , Kornelia Polyak (9) , Beth Overmoyer (10) , Gayathri Devi (11) , Esta Sterneck (12) , Robert Schneider (13, 14) , Bisrat Debeb (15) , Xiaoping Wang (15) , Kenneth van Golen (16) , Randa El-Zein (17, 1) , Omar Rahal (15) , Angela Alexander (15, 18) , James Reuben (15) , Savitri Krishnamurthy (19) , Anthony Lucci (15) , Naoto Ueno (15)

1 The University of Texas M.D. Anderson Cancer Center [Houston]
2 Northwestern University Feinberg School of Medicine
3 Department of Inteernal Medicine
4 University of Michigan Medical School [Ann Arbor]
5 CORE - Center for Oncological Research [Antwerp, Belgium]
6 Department of Neuroscience, Yale University School of Medicine
7 CRCM - Centre de Recherche en Cancérologie de Marseille
8 Institute of Cancer and Genomic Sciences, University of Birmingham
9 Department of Medical Oncology
10 Dana-Farber Cancer Institute [Boston]
11 Duke University Medical Center
12 FNLCR - Frederick National Laboratory for Cancer Research
13 NYU - New York University School of Medicine
14 NYUP2C - NYU Perlmutter Cancer Center [New York, NY, USA]
15 MD Anderson Cancer Center [Houston]
16 University of Delaware [Newark]
17 Houston Methodist Research Institute
18 The University of Texas Medical School at Houston
19 CSE - Department of Computer Science & Engineering [Riverside]

In 2006, a remarkable collaboration between University of Texas MD Anderson Cancer Center clinicians and Texas and New Mexico State legislators led to the formation of a dedicated IBC Research Program and Clinic at MD Anderson. This initiative provided funding and infrastructure to foster coordination of an IBC World Consortium of national and international experts, and launch the first ever IBC international conference in 2008, which brought together experts from around the world to facilitate collaborations and accelerate progress. Indeed great progress has been made since then. National and international experts in IBC convened at the 10th Anniversary Conference of the MD Anderson IBC Clinic and Research Program and presented the most extensive sequencing analysis to date comparing IBC to non-IBC, gene- and protein-based immunoprofiling of IBC versus non-IBC patients, and converging lines of evidence on the specific role of the microenvironment in IBC. Novel models, unique metabolic mechanisms, and prominent survival pathways have been identified and were presented. Multiple clinical trials based on the work of the last decade are in progress or in development. The important challenges ahead were discussed. This progress and a coordinated summary of these works are presented herein.

Domains: Life Sciences [q-bio]; Cancer

Wendy Woodward, Massimo Cristofanilli, Sofia Merajver, Steven van Laere, Lajos Pusztai, et al.. Scientific summary from the Morgan Welch MD Anderson Cancer Center Inflammatory Breast Cancer (IBC) program 10th Anniversary Conference. Journal of Cancer, 2017, 8 (17), pp.3607-3614. ⟨10.7150/jca.21200⟩. ⟨hal-03623708⟩