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Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the Literature

Abstract : Synovial sarcoma (SVS) of the thyroid gland is exceedingly rare. We report thecase of a 55-year-old man with a rapidlygrowing 7-cm neck mass. Because ofsuspicion of anaplastic thyroid carcinoma, a total thyroidectomy was planned, without preoperative cytology. During surgery, the tumor ruptured,leading to fragmented and incomplete resection. The morpho-logical and immunohistochemical aspects suggestedthyroid SVS,whichwas confirmed by fluorescent in situ hybridization (SYTgene rearrangement). The patient experienced immediate local relapse in close contact with large vessels and the thyroid cartilage and was referred to our institution. Doxorubicin-ifosfamide chemotherapy led to a minor response that authorized secondary conservative surgery. Because of microscopically incomplete resection, adjuvant radiotherapy was chosenand is ongoing 10 months after initial surgery. The prognosis of thyroid SVS is associated with a highrisk for local and metastatic relapses. Pretreatment diagnosis is fundamental and may benefit from molecular analysis. Margin-free monobloc surgical excision is the best chance for cure, but adjuvant chemotherapy and radiotherapy deserve to be discussed.
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Submitted on : Thursday, March 31, 2022 - 7:14:50 AM
Last modification on : Thursday, March 31, 2022 - 6:13:36 PM

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Laurys Boudin, Nicolas Fakhry, Bruno Chetaille, Delphine Perrot, Anh Tuan Nguyen, et al.. Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the Literature. Case Reports in Oncology, Basel : Karger, 2014, 7 (1), pp.6-13. ⟨10.1159/000357913⟩. ⟨hal-03623760⟩

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