Impact of radiotherapy in the management of locally advanced extrahepatic cholangiocarcinoma

Laurence Moureau-Zabotto (1) , Olivier Turrini (2) , Michel Resbeut (3) , Jean-Luc Raoul (1) , Marc Giovannini (1) , Flora Poizat (4) , Gilles Piana (1) , Jean-Robert Delpero (2) , François Bertucci (5)

1 IPC - Institut Paoli-Calmettes
2 Department of Surgical Oncology
3 Département de Radiothérapie
4 Service de Biopathologie [CHRU Montpellier]
5 CRCM - Centre de Recherche en Cancérologie de Marseille

Background Optimal therapy for patients with unresectable locally advanced extrahepatic cholangiocarcinoma (ULAC) remains controversial. We analysed the role of radiotherapy in the management of such tumors. Methods We retrospectively reviewed the charts of patients treated in our institution with conformal-3D external-beam-radiotherapy (EBRT) with or without concurrent chemotherapy. Results Thirty patients were included: 24 with a primary tumor (group 1) and 6 with a local relapse (group 2). Toxicity was low. Among 25 patients assessable for EBRT response, we observed 9 complete responses, 4 partial responses, 10 stabilisations, and 2 progressions. The median follow-up was 12 months. Twenty out of 30 patients (66%) experienced a relapse, which was metastatic in 75% of cases in the whole series, 87% in group 1, 60% in group 2 (p = 0.25). Twenty-eight patients (93%) died of relapse or disease complications. Median overall survivals in the whole group and in group 1 or 2 were respectively 12, 11 and 21 months (p = 0.11). The 1-year and 3-year progression-free survivals were respectively 38% and 16% in the whole series; 31% and 11% in group 1, 67% and 33% in group 2 (p = 0.35). Conclusion EBRT seems efficient to treat ULAC, with acceptable toxicity. For primary disease, the high rate of metastatic relapse suggests to limit EBRT to non-progressive patients after induction chemotherapy.

Mots clés: Inoperable cholangiocarcinoma; Radiotherapy; Chemotherapy; Outcome

Domaines: Cancer

Laurence Moureau-Zabotto, Olivier Turrini, Michel Resbeut, Jean-Luc Raoul, Marc Giovannini, et al.. Impact of radiotherapy in the management of locally advanced extrahepatic cholangiocarcinoma. BMC Cancer, 2013, 13 (1), pp.568. ⟨10.1186/1471-2407-13-568⟩. ⟨hal-03623761⟩