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Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers

Hiroko Masuda 1 Keith Baggerly 1 Ying Wang 1 Takayuki Iwamoto Takae Brewer 1 Lajos Pusztai 1 Kazuharu Kai 1 Takahiro Kogawa 1 Pascal Finetti 2 Daniel Birnbaum 2 Luc Dirix Wendy Woodward 1 James Reuben 1 Savitri Krishnamurthy 1 W Fraser Symmans 1 Steven van Laere 3 François Bertucci 2 Gabriel Hortobagyi 1 Naoto Ueno 1
1 The University of Texas M.D. Anderson Cancer Center [Houston]
2 Institut Paoli-Calmettes
3 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
Abstract : Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients. Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes. Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort. Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.
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Submitted on : Tuesday, March 29, 2022 - 7:14:50 PM
Last modification on : Saturday, April 2, 2022 - 3:34:20 AM

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Hiroko Masuda, Keith Baggerly, Ying Wang, Takayuki Iwamoto, Takae Brewer, et al.. Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers. Breast Cancer Research, BioMed Central, 2013, 15 (6), pp.R112. ⟨10.1186/bcr3579⟩. ⟨hal-03623763⟩

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