Bacterial Iron Homeostasis Regulation by sRNAs - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Microbiology Spectrum Année : 2018

Bacterial Iron Homeostasis Regulation by sRNAs

Résumé

ABSTRACT While iron is essential to sustain growth, its excess can be detrimental to the cell by generating highly toxic reactive oxygen species. Regulation of iron homeostasis thus plays a vital role in almost all living organisms. During the last 15 years, the small RNA (sRNA) RyhB has been shown to be a key actor of iron homeostasis regulation in bacteria. Through multiple molecular mechanisms, RyhB represses expendable iron-utilizing proteins, promotes siderophore production, and coordinates Fe-S cluster cofactor biogenesis, thereby establishing a so-called iron-sparing response. In this review, we will summarize knowledge on how sRNAs control iron homeostasis mainly through studies on RyhB in Escherichia coli . The parallel roles and modes of action of other sRNAs in different bacteria will also be described. Finally, we will discuss what questions remain to be answered concerning this important stress response regulation by sRNAs.
Fichier non déposé

Dates et versions

hal-03641978 , version 1 (14-04-2022)

Identifiants

Citer

Sylvia Chareyre, Pierre Mandin. Bacterial Iron Homeostasis Regulation by sRNAs. Microbiology Spectrum, 2018, 6 (2), ⟨10.1128/microbiolspec.RWR-0010-2017⟩. ⟨hal-03641978⟩

Collections

CNRS UNIV-AMU FRM
6 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More