HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Adenosine Receptor Reserve and Long-Term Potentiation: Unconventional Adaptive Mechanisms in Cardiovascular Diseases?

Abstract : While the concept of a receptor reserve (spare receptors) is old, their presence on human cells as an adaptive mechanism in cardiovascular disease is a new suggestion. The presence of spare receptors is suspected when the activation of a weak fraction of receptors leads to maximal biological effects, in other words, when the half-maximal effective concentration (EC50) for a biological effect (cAMP production, for example) is lower than the affinity (KD) of the ligand for a receptor. Adenosine is an ATP derivative that strongly impacts the cardiovascular system via its four membrane receptors, named A1R, A2AR, A2BR, and A3R, with the A1R being more particularly involved in heart rhythm, while the A2AR controls vasodilation. After a general description of the tools necessary to explore the presence of spare receptors, this review focuses on the consequences of the presence of spare adenosine receptors in cardiovascular physiopathology. Finally, the role of the adenosinergic system in the long-term potentiation and its possible consequences on the physiopathology are also mentioned.
Document type :
Journal articles
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03653502
Contributor : Guillaume Ranchon Connect in order to contact the contributor
Submitted on : Wednesday, April 27, 2022 - 6:13:16 PM
Last modification on : Tuesday, May 3, 2022 - 10:00:40 AM

Links full text

Identifiers

Collections

Citation

Régis Guieu, Michele Brignole, Jean Claude Deharo, Pierre Deharo, Giovanna Mottola, et al.. Adenosine Receptor Reserve and Long-Term Potentiation: Unconventional Adaptive Mechanisms in Cardiovascular Diseases?. International Journal of Molecular Sciences, MDPI, 2021, 22 (14), pp.7584. ⟨10.3390/ijms22147584⟩. ⟨hal-03653502⟩

Share

Metrics

Record views

0