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The interferon landscape along the respiratory tract impacts the severity of COVID-19

Benedetta Sposito 1 Achille Broggi 1, 2 Laura Pandolfi 3 Stefania Crotta 4 Nicola Clementi 5 Roberto Ferrarese 5 Sofia Sisti 5 Elena Criscuolo 5 Roberto Spreafico 6 Jaclyn Long 1 Alessandro Ambrosi 5 Enju Liu 7 Vanessa Frangipane 3 Laura Saracino 3 Sara Bozzini 3 Laura Marongiu 8 Fabio Facchini 8 Andrea Bottazzi 3 Tommaso Fossali 9 Riccardo Colombo 10 Massimo Clementi 5 Elena Tagliabue 11 Janet Chou 12 Antonio Pontiroli 13 Federica Meloni 14 Andreas Wack 4 Nicasio Mancini 15 Ivan Zanoni 1 
1 HMS - Harvard Medical School [Boston]
2 CIML - Centre d'Immunologie de Marseille - Luminy
3 UNIPV - Università degli Studi di Pavia = University of Pavia
4 The Francis Crick Institute [London]
5 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
6 Institute for Quantitative and Computational Biosciences - University of california LA
7 Division of Gastroenterology [Boston, MA, USA]
8 DIMET - Dipartimento di Informatica, Matematica, Elettronica e Trasporti [Reggio Calabria]
9 Luigi sacco hospital - Division of Anesthesiology and intensive Care
10 Luigi sacco hospital - Division of Anesthesiology and intensive Care
11 IRCCS Multimedica
12 Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
13 UNIMI - Università degli Studi di Milano = University of Milan
14 IRCCS - Division of Respiratory Diseases
15 IRCCS laboratory of medical microbiology and virology Milan
Keywords : interferon Type I IFN Type III IFN COVID-19 SARS-CoV-2 dendritic cell epithelial cell pattern recognition receptor lung airways
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Journal articles
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https://hal-amu.archives-ouvertes.fr/hal-03659222
Contributor : Anita DUMENIL Connect in order to contact the contributor
Submitted on : Wednesday, May 4, 2022 - 5:56:33 PM
Last modification on : Monday, November 28, 2022 - 8:22:06 PM

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Benedetta Sposito, Achille Broggi, Laura Pandolfi, Stefania Crotta, Nicola Clementi, et al.. The interferon landscape along the respiratory tract impacts the severity of COVID-19. Cell, 2021, 184 (19), pp.4953-4968.e16. ⟨10.1016/j.cell.2021.08.016⟩. ⟨hal-03659222⟩

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