The interferon landscape along the respiratory tract impacts the severity of COVID-19

Benedetta Sposito (1) , Achille Broggi (1, 2) , Laura Pandolfi (3) , Stefania Crotta (4) , Nicola Clementi (5) , Roberto Ferrarese (5) , Sofia Sisti (5) , Elena Criscuolo (5) , Roberto Spreafico (6) , Jaclyn Long (1) , Alessandro Ambrosi (5) , Enju Liu (7) , Vanessa Frangipane (3) , Laura Saracino (3) , Sara Bozzini (3) , Laura Marongiu (8) , Fabio Facchini (8) , Andrea Bottazzi (3) , Tommaso Fossali (9) , Riccardo Colombo (10) , Massimo Clementi (5) , Elena Tagliabue (11) , Janet Chou (12) , Antonio Pontiroli (13) , Federica Meloni (14) , Andreas Wack (4) , Nicasio Mancini (15) , Ivan Zanoni (1)

1 HMS - Harvard Medical School [Boston]
2 CIML - Centre d'Immunologie de Marseille - Luminy
3 UNIPV - Università degli Studi di Pavia = University of Pavia
4 The Francis Crick Institute [London]
5 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
6 Institute for Quantitative and Computational Biosciences - University of california LA
7 Division of Gastroenterology [Boston, MA, USA]
8 DIMET - Dipartimento di Informatica, Matematica, Elettronica e Trasporti [Reggio Calabria]
9 Luigi sacco hospital - Division of Anesthesiology and intensive Care
10 Luigi sacco hospital - Division of Anesthesiology and intensive Care
11 IRCCS Multimedica
12 Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
13 UNIMI - Università degli Studi di Milano = University of Milan
14 IRCCS - Division of Respiratory Diseases
15 IRCCS laboratory of medical microbiology and virology Milan

Keywords: interferon; Type I IFN; Type III IFN; COVID-19; SARS-CoV-2; dendritic cell; epithelial cell; pattern recognition receptor; lung; airways

Domains: Life Sciences [q-bio]

Benedetta Sposito, Achille Broggi, Laura Pandolfi, Stefania Crotta, Nicola Clementi, et al.. The interferon landscape along the respiratory tract impacts the severity of COVID-19. Cell, 2021, 184 (19), pp.4953-4968.e16. ⟨10.1016/j.cell.2021.08.016⟩. ⟨hal-03659222⟩