Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation

Valentina Poli (1) , Victor Pui-Yan Ma (2, 3) , Marco Di Gioia (1) , Achille Broggi (1, 4) , Mehdi Benamar (1) , Qian Chen (1) , Ralph Mazitschek (5, 6, 7) , Stephen Haggarty (8) , Talal Chatila (1) , Jeffrey Karp (2, 7, 9, 10) , Ivan Zanoni (1, 11)

1 Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
2 BWH - Brigham & Women’s Hospital [Boston]
3 HMS - Harvard Medical School [Boston]
4 CIML - Centre d'Immunologie de Marseille - Luminy
5 Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital
6 Harvard T.H. Chan School of Public Health
7 Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
8 Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston
9 Harvard-MIT Division of Health Sciences and Technology [Cambridge]
10 HSCI - Harvard Stem Cell Institute [Cambridge, USA]
11 Harvard Medical School - Division of gastroenterology

Domains: Life Sciences [q-bio]

Valentina Poli, Victor Pui-Yan Ma, Marco Di Gioia, Achille Broggi, Mehdi Benamar, et al.. Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation. iScience, 2021, 24 (11), pp.103256. ⟨10.1016/j.isci.2021.103256⟩. ⟨hal-03659235⟩