HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue

Abstract : Obesity is a significant risk factor for arrhythmic cardiovascular death. Interactions between epicardial adipose tissue (EAT) and myocytes are thought to play a key role in the development of arrhythmias. In this review, the authors investigate the influence of EAT on arrhythmogenesis. First, they summarize electrocardiographic evidence showing the association between increased EAT volume and atrial and ventricular conduction delay. Second, they detail the structural cross talk between EAT and the heart and its arrhythmogenicity. Adipose tissue infiltration within the myocardium constitutes an anatomical obstacle to cardiac excitation. It causes activation delay and increases the risk of arrhythmias. Intercellular electrical coupling between cardiomyocytes and EAT can further slow conduction and increase the risk of block, favoring re-entry and arrhythmias. Finally, EAT secretes multiple substances that influence cardiomyocyte electrophysiology either by modulating ion currents and electrical coupling or by stimulating fibrosis. Thus, structural and paracrine cross talk between EAT and cardiomyocytes facilitates arrhythmias.
Document type :
Journal articles
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03662340
Contributor : Valérie Gall Connect in order to contact the contributor
Submitted on : Monday, May 9, 2022 - 11:48:12 AM
Last modification on : Tuesday, May 10, 2022 - 11:58:15 AM

Links full text

Identifiers

Collections

Citation

Auriane Ernault, Veronique M.F. Meijborg, Ruben Coronel. Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue. Journal of the American College of Cardiology, Elsevier, 2021, 78 (17), pp.1730-1745. ⟨10.1016/j.jacc.2021.08.037⟩. ⟨hal-03662340⟩

Share

Metrics

Record views

0