Disparities in Intensive Care Unit Admission and Mortality Among Patients With Schizophrenia and COVID-19: A National Cohort Study - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Schizophrenia Bulletin Année : 2021

Disparities in Intensive Care Unit Admission and Mortality Among Patients With Schizophrenia and COVID-19: A National Cohort Study

Guillaume Fond
Vanessa Pauly
  • Fonction : Auteur
Pierre-Michel Llorca
Veronica Orleans
  • Fonction : Auteur
Anderson Loundou
Christophe Lancon
  • Fonction : Auteur
Pascal Auquier
  • Fonction : Auteur
Karine Baumstarck
  • Fonction : Auteur
Laurent Boyer

Résumé

Abstract Patients with schizophrenia (SCZ) represent a vulnerable population who have been understudied in COVID-19 research. We aimed to establish whether health outcomes and care differed between patients with SCZ and patients without a diagnosis of severe mental illness. We conducted a population-based cohort study of all patients with identified COVID-19 and respiratory symptoms who were hospitalized in France between February and June 2020. Cases were patients who had a diagnosis of SCZ. Controls were patients who did not have a diagnosis of severe mental illness. The outcomes were in-hospital mortality and intensive care unit (ICU) admission. A total of 50 750 patients were included, of whom 823 were SCZ patients (1.6%). The SCZ patients had an increased in-hospital mortality (25.6% vs 21.7%; adjusted OR 1.30 [95% CI, 1.08–1.56], P = .0093) and a decreased ICU admission rate (23.7% vs 28.4%; adjusted OR, 0.75 [95% CI, 0.62–0.91], P = .0062) compared with controls. Significant interactions between SCZ and age for mortality and ICU admission were observed (P = .0006 and P < .0001). SCZ patients between 65 and 80 years had a significantly higher risk of death than controls of the same age (+7.89%). SCZ patients younger than 55 years had more ICU admissions (+13.93%) and SCZ patients between 65 and 80 years and older than 80 years had less ICU admissions than controls of the same age (−15.44% and −5.93%, respectively). Our findings report the existence of disparities in health and health care between SCZ patients and patients without a diagnosis of severe mental illness. These disparities differed according to the age and clinical profile of SCZ patients, suggesting the importance of personalized COVID-19 clinical management and health care strategies before, during, and after hospitalization for reducing health disparities in this vulnerable population.

Dates et versions

hal-03666066 , version 1 (12-05-2022)

Identifiants

Citer

Guillaume Fond, Vanessa Pauly, Marc Leone, Pierre-Michel Llorca, Veronica Orleans, et al.. Disparities in Intensive Care Unit Admission and Mortality Among Patients With Schizophrenia and COVID-19: A National Cohort Study. Schizophrenia Bulletin, 2021, 47 (3), pp.624-634. ⟨10.1093/schbul/sbaa158⟩. ⟨hal-03666066⟩

Collections

CNRS UNIV-AMU
7 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More