Skip to Main content Skip to Navigation
New interface
Journal articles

From Species to Regional and Local Specialization of Intestinal Macrophages

Abstract : Initially intended for nutrient uptake, phagocytosis represents a central mechanism of debris removal and host defense against invading pathogens through the entire animal kingdom. In vertebrates and also many invertebrates, macrophages (MFs) and MF-like cells (e.g., coelomocytes and hemocytes) are professional phagocytic cells that seed tissues to maintain homeostasis through pathogen killing, efferocytosis and tissue shaping, repair, and remodeling. Some MF functions are common to all species and tissues, whereas others are specific to their homing tissue. Indeed, shaped by their microenvironment, MFs become adapted to perform particular functions, highlighting their great plasticity and giving rise to high population diversity. Interestingly, the gut displays several anatomic and functional compartments with large pools of strikingly diversified MF populations. This review focuses on recent advances on intestinal MFs in several species, which have allowed to infer their specificity and functions.
Document type :
Journal articles
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03669820
Contributor : Julie TOMAS Connect in order to contact the contributor
Submitted on : Tuesday, May 17, 2022 - 8:43:07 AM
Last modification on : Wednesday, May 18, 2022 - 11:40:53 AM

Links full text

Identifiers

Collections

Citation

Cynthia Arroyo Portilla, Julie Tomas, Jean-Pierre Gorvel, Hugues Lelouard. From Species to Regional and Local Specialization of Intestinal Macrophages. Frontiers in Cell and Developmental Biology, 2021, 8, ⟨10.3389/fcell.2020.624213⟩. ⟨hal-03669820⟩

Share

Metrics

Record views

8